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Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes.
Toxins (Basel)
December 2024
Division of Toxicology, Institute for Medical Research and Occupational Health, HR-10 000 Zagreb, Croatia.
The increasing use of products for medicinal, dietary, and recreational purposes has raised concerns about mycotoxin contamination in cannabis and hemp. Mycotoxins persist in these products' post-processing, posing health risks via multiple exposure routes. This study investigated cytotoxic and genotoxic interactions between cannabidiol (CBD) and the mycotoxin citrinin (CIT) using human cell models: SH-SY5Y, HepG2, HEK293, and peripheral blood lymphocytes.
View Article and Find Full Text PDFPlant-derived compounds and neurodegenerative diseases: Different mechanisms of action with therapeutic potential.
Neuroscience
February 2025
Laboratorio de Mecanismos de Neurodegeneración y Neuroprotección, Departamento de Neurobiología y Neuropatología, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; Neuroactive Natural Compounds UNESCO Chair, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay. Electronic address:
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of discrete groups of neurons causing severe disability. The main risk factor is age, hence their incidence is rapidly increasing worldwide due to the rise in life expectancy. Although the causes of the disease are not identified in about 90% of the cases, in the last decades there has been great progress in understanding the basis for neurodegeneration.
View Article and Find Full Text PDFAnxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches.
Behav Brain Res
March 2025
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj 8100, Bangladesh; Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address:
Background: Anxiety disorder is the most common mental illness and a major contributor to impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety. It is widely recognized that the neurobiology of anxiety-related behavior involves GABAergic systems.
View Article and Find Full Text PDFAssessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking.
Sleep Med
February 2025
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Dhaka, Bangladesh; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. Electronic address:
Article Synopsis
- The study examined the sedative effects of Chrysin (CHR) on sleep in mice, and its interaction with diazepam (DZP) and flumazenil (FLU), using thiopental sodium to induce sleep.
- Results showed that CHR significantly decreased the time it took for mice to fall asleep and increased total sleep duration, with the most effective dose being 10 mg/kg.
- Molecular docking studies indicated that CHR binds more strongly to GABA receptors than DZP and FLU, suggesting its potential to enhance traditional sedatives and warranting further research for clinical applications.
Cupressus torulosa, a Source of Antioxidant Polyphenols: An Analytical and Pharmacological Study.
Rapid Commun Mass Spectrom
February 2025
Chemistry & Bioprospecting Division, Forest Research Institute, Dehradun, India.
Article Synopsis
- Cupressus torulosa, an aromatic conifer from the northwestern Himalayas, has traditionally been valued for its various medicinal properties, including anti-inflammatory and antioxidant effects.
- The study utilized multiple methods to assess the antioxidant potential of the tree's needles, revealing a promising 25% aqueous methanol extract and significant results from the ethyl acetate fraction with notable free radical scavenging activity.
- These findings highlight C. torulosa as a potential source of bioactive antioxidants, paving the way for future research into its applications in pharmaceuticals and natural health products for combating oxidative stress-related diseases.
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