Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on pain sensitivity is probably mediated by short-term glucocorticoid-independent and long-term glucocorticoid-dependent mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/a:1017609726742 | DOI Listing |
Publication Analysis
Top Keywords
acth pain
8
pain sensitivity
8
sensitivity rats
4
rats systemic
4
systemic administration
4
administration acth
4
acth rats
4
rats normal
4
normal hormone
4
hormone production
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!