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Identification of post-translationally modified proteins in proteome studies. | LitMetric

Proteome studies are powerful tools to solve many different problems in metabolism, signal transduction, drug discovery, and other areas of interest in life sciences. Up to now, high-sensitive methods for protein identification after two-dimensional gel electrophoresis using mass spectrometry are available. However, the identification of post-translational modifications after two-dimensional gel electrophoresis is still an unsolved problem. In this paper, we want to give several examples for the successful identification of post-translational modifications and point mutations.

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http://dx.doi.org/10.1002/1522-2683(200105)22:9<1669::AID-ELPS1669>3.0.CO;2-7DOI Listing

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