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Introduction: Body composition is studied in athletes as a means of measuring physical fitness and progression of training. Athletes can utilize body composition in multiple ways to guide training toward athlete specific goals. Several different methods exist with varying levels of cost, invasiveness, reading complexity, and availability.
View Article and Find Full Text PDFNeuroreceptor Mapping in 2024.
ACS Chem Neurosci
December 2024
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Neuroreceptor mapping provides insights into neurotransmitter changes and receptor dynamics that improve the understanding of brain functions. This Viewpoint highlights the advancements in the development of novel radiotracers (imaging tools) and quantification of receptor dynamics based on presentations from the , 2024. The Viewpoint also emphasizes the applications of neuroreceptor mapping in clinical research and the latest technologies for imaging the brain with positron emission tomography (PET).
View Article and Find Full Text PDFComparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease.
Nat Commun
November 2024
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes. Here, we update and complement previous findings from the Dominantly Inherited Alzheimer Network Observational Study by using matched cross-sectional and longitudinal cerebrospinal fluid (CSF) and plasma samples from 567 individuals, allowing timely comparative analyses of CSF and blood trajectories across the entire disease spectrum.
View Article and Find Full Text PDFAdvancing Digital Education Technologies by Empowering Nurses With Point-of-Care Ultrasound: Protocol for a Mixed Methods Study.
JMIR Res Protoc
October 2024
Ribeirão Preto College of Nursing, University of São Paulo, Ribeirão Preto, Brazil.
Background: Bedside ultrasonography, also known as point-of-care ultrasound (PoCUS), is a promising technological tool that enhances clinical assessment, enriching diagnostic capabilities and clinical reasoning. Its use in nursing spans various patient populations and health care settings, providing nurses with a valuable health assessment tool to improve care quality and patient safety. Despite its growing integration into clinical practice, PoCUS training has mainly focused on physicians, leaving a gap for trained nurses who demonstrate similar proficiency in conducting scans and interpreting images.
View Article and Find Full Text PDFRelationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology.
EBioMedicine
November 2024
AI(2)D, Center for AI and Data Science for Integrated Diagnostics, and Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Background: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD).
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