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Combination Therapy With Risperidone and High-Dose Melatonin Is Effective Despite Reversible Side Effects Including Breast Budding.
Cureus
November 2024
Pediatrics, Child and Parents Support Clinic, Ebina, JPN.
Melatonin is commonly used to treat sleep disorders. Regardless of the prolactin level elevation induced by melatonin administration, breast budding is not known to develop as a result of this treatment. A 10-year-old boy presented to our outpatient clinic with restlessness and sleep disorders.
View Article and Find Full Text PDFIdentification, annotation and toxicity estimation of organic pollutants in human serum via non-target analysis.
Environ Pollut
December 2024
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, People's Republic of China.
Environmental organic pollution causes a threat to the ecological environment, constrains social development and can also potentially harm human health. We applied non-target analysis to screen organic pollutants from the serum of 89 individuals, identifying 67 pollutants in the categories of industrial intermediates, plasticizers, surfactants, pharmaceuticals, pesticides, and exogenous pollutant metabolites. The detection rate of chemicals for industrial use (50.
View Article and Find Full Text PDFA Rare Case of Dose-Dependent Priapism in a Child with Autism Treated with Aripiprazole and Risperidone.
J Child Adolesc Psychopharmacol
December 2024
Child and Adolescent Psychiatry Department, Ümit Işık Academy, Isparta, Turkey.
Physiologically based pharmacokinetic modeling to predict the effect of risperidone on aripiprazole pharmacokinetics in subjects with different CYP2D6 genotypes and individuals with hepatic impairment.
Ther Adv Drug Saf
December 2024
Genetics and Biochemistry Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
Background: Aripiprazole and risperidone, widely used atypical antipsychotics, are commonly adjunctively prescribed in clinical practice. When aripiprazole was combined with risperidone, the genotype of drug-metabolizing enzymes and liver impairment may lead to complex pharmacokinetic changes. The Physiologically Based Pharmacokinetic (PBPK) model can predict the influence of these factors on plasma concentration and optimize dosage regimens.
View Article and Find Full Text PDFUnderstanding De Novo Bupropion-Induced Psychosis and Its Management Strategies: A Case Report and Literature Review.
Cureus
November 2024
Psychiatry and Psychotherapy Department, Klinikum Mutterhaus der Borromäerinnen, Trier, DEU.
Psychotic manifestations of iatrogenic origin are common in clinical practice, and it is essential to rule out organic and iatrogenic causes before attributing symptoms to psychiatric disorders. Bupropion, an atypical antidepressant used for treating depression and aiding smoking cessation, has been linked to rare instances of psychosis, especially in patients with risk factors like substance use, older age, or history of head trauma. This report describes the case of a 52-year-old man with recurrent depression who developed a bupropion-induced psychotic episode following an increase in dose to 300 mg/day.
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