Cord blood transferrin receptors to assess fetal iron status.

Arch Dis Child Fetal Neonatal Ed

Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland.

Published: July 2001

Objective: To study iron status at different gestational ages using cord blood serum transferrin receptors (STfRs).

Methods: STfRs, iron, ferritin, total iron binding capacity, haemoglobin, and reticulocytes were measured in 144 cord blood samples. The babies were divided into three groups according to gestation (26 very preterm (24-29 weeks); 50 preterm (30-36 weeks); 68 term (37-41 weeks)).

Results: Serum iron, ferritin, and total iron binding capacity were highest at term, whereas reticulocytes were highest in the very preterm. STfR levels were not influenced by gestation. Haemoglobin (r = 0.46; p < 0.0001) and reticulocytes (r = 0.42; p < 0.0001) were the only indices that independently correlated with STfR levels.

Conclusions: STfR levels in cord blood are not directly influenced by gestation and probably reflect the iron requirements of the fetus for erythropoiesis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721275PMC
http://dx.doi.org/10.1136/fn.85.1.f46DOI Listing

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