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Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania.
Cell Rep
September 2024
Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China; Jinhua Institute of Zhejiang University, Jinhua, Zhejiang 321299, China. Electronic address:
Hyperfunction of the dopamine system has been implicated in manic episodes in bipolar disorders. How dopaminergic neuronal function is regulated in the pathogenesis of mania remains unclear. Histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei.
View Article and Find Full Text PDFPharmacological characterization of the zebrafish Hrh2a histamine H receptor.
Eur J Pharmacol
October 2024
Amsterdam Institute for Molecules, Medicines, and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands. Electronic address:
The zebrafish, Danio rerio, is a widely adopted in vivo model that conserves organs such as the liver, kidney, stomach, and brain, being, therefore, suitable for studying human diseases, drug discovery and toxicology. The brain aminergic systems are also conserved and the histamine H, H and H receptors were previously cloned and identified in the zebrafish brain. Genome studies identified another putative H receptor (Hrh2) with ∼50% sequence identity with H receptor orthologs.
View Article and Find Full Text PDFStimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice.
Behav Pharmacol
September 2024
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, Chhattisgarh, India.
Diazepam administration has been shown to influence the release of histamine in various brain areas involved in motor behavior. Therefore, the present study explored the plausible regulatory role of the central histaminergic system in diazepam-induced deficits in motor performance in mice using the rota-rod and beam walking tests. In this study, several doses of diazepam (0.
View Article and Find Full Text PDFSelective histamine H receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice.
J Pharmacol Sci
November 2022
Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H receptors. Herein, we investigated the effects of H receptor agonists on the blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). Male ddY mice were used to generate the TBI model, in which a fluid percussion injury (FPI) was induced by a hydraulic impact.
View Article and Find Full Text PDFAn H2R-dependent medial septum histaminergic circuit mediates feeding behavior.
Curr Biol
May 2022
Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road, Hangzhou 310058, China; Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Binwen Road, Hangzhou 310053, China; Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road, Hangzhou 310009, Zhejiang, China. Electronic address:
Novel targets for treating feeding-related diseases are of great importance, and histamine has long been considered an anorexigenic agent. However, understanding its functions in feeding in a circuit-specific way is still limited. Here, we report a medial septum (MS)-projecting histaminergic circuit mediating feeding behavior.
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