AI Article Synopsis
- Practitioners of traditional Indian medicine consider Withania somnifera Dun. (commonly known as 'Indian ginseng') for its health benefits, particularly for its potential antistress properties.
- A new aqueous fraction from the plant's roots, free of withanolides, was tested on various stress-related measures, showing significant antistress effects in a dose-dependent manner.
- The safety profile of this extract was assessed in mice, indicating a good margin of safety compared to a commercially available root extract.
Article Abstract
The practitioners of the traditional Indian system of medicine regard Withania somnifera Dun. as the 'Indian ginseng'. A new withanolide-free aqueous fraction was isolated from the roots of this plant and was evaluated for putative antistress activity against a battery of tests such as hypoxia time, antifatigue effect, swimming performance time, swimming induced gastric ulceration and hypothermia, immobilization induced gastric ulceration, autoanalgesia and biochemical changes in the adrenal glands. This bioactive fraction exhibited significant antistress activity in a dose-related manner in all the parameters studied. The extract of Withania somnifera root (a commercial preparation available locally) was used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.858 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!