Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
In vitro and in vivo immune-enhancing effects of polysaccharides with different molecular weights and structural characteristics from Gastrodia elata Blume.
Int J Biol Macromol
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao. Electronic address:
Research on high-molecular-weight polysaccharides tends to be more difficult and lag in terms of their fine structures and bioavailability. We focused on Gastrodia elata Blume polysaccharides (GEPs) with different molecular weights and structural characteristics to reveal their bioactivities, especially those abundant high-molecular-weight GEPs. A novel high-yield polysaccharide (GEP1-2) with the high molecular weight of 3.
View Article and Find Full Text PDFSERCA Modulators Reveal Distinct Signaling and Functional Roles of T Lymphocyte Ca Stores.
Int J Mol Sci
November 2024
Department of Pharmaceutical Sciences, Thomas J. Long School of Pharmacy University of the Pacific, Stockton, CA 95211, USA.
The allosteric SERCA (Sarcoplasmic/Endoplasmic Reticulum Ca-ATPase) activator CDN1163 has been recently added to the group of pharmacological tools for probing SERCA function. We chose to investigate the effects of the compound on T lymphocyte Ca stores, using the well-described Jurkat T lymphocyte as a reliable cell system for Ca signaling pathways. Our study identified the lowest concentrations of the SERCA inhibitors thapsigargin (TG) and 2,5-di-( butyl)-1,4-benzohydroquinone (tBHQ) capable of releasing Ca, permitting the differentiation of the TG-sensitive SERCA 2b Ca store from the tBHQ-sensitive SERCA 3 Ca store.
View Article and Find Full Text PDFAutomating cancer diagnosis using advanced deep learning techniques for multi-cancer image classification.
Sci Rep
October 2024
School of IT and Engineering, Melbourne Institute of Technology, Melbourne, 3000, Australia.
Cancer detection poses a significant challenge for researchers and clinical experts due to its status as the leading cause of global mortality. Early detection is crucial, but traditional cancer detection methods often rely on invasive procedures and time-consuming analyses, creating a demand for more efficient and accurate solutions. This paper addresses these challenges by utilizing automated cancer detection through AI-based techniques, specifically focusing on deep learning models.
View Article and Find Full Text PDFChronic Spontaneous Urticaria: Current and Emerging Biologic Agents.
Immunol Allergy Clin North Am
November 2024
Department of Allergy and Clinical Immunology, Cleveland Clinic, 9500 Euclid Avenue, A90, Cleveland, OH 44195, USA. Electronic address:
Article Synopsis
- Antihistamine refractory chronic spontaneous urticaria (CSU) affects up to 50% of patients, indicating a need for better treatment options.
- Anti-immunoglobulin E (IgE) therapies have transformed CSU management, but there are still instances where these treatments fail, highlighting the necessity for alternative biologic therapies.
- The review discusses not only anti-IgE and Th2-targeted therapies but also explores new approaches targeting different pathways of mast cell activation, potentially offering more effective treatments for those resistant to standard therapies.
The Controlling Nutritional Status (CONUT) Score Predicts Post-operatory Risks and Prognosis in Patients With Surgically Treated Colon Cancer: A Retrospective Study.
Anticancer Res
September 2024
Department of Medicine and Surgery, University of Parma, Parma, Italy.
Background/aim: The Controlling Nutritional status (CONUT) score, a valuable tool evaluating the preoperative conditions of patients from a nutritional point of view, has been successfully adopted for a plethora of malignancies including colorectal cancer (CRC). However, since rectal cancer has characteristics that differ from colon cancer (CC) and because, as of 2024, investigations targeted to surgical CC patients are lacking in the pertinent literature, we decided to assess the predictive role of this scoring system in relation to postoperative course and survival of surgical patients affected only by this malignancy. However, as of 2024, the existing literature on CONUT has typically treated colorectal cancer (CRC) as a single homogeneous entity, often combining results for both colon cancer (CC) and rectal cancer (RC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!