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Objective: To evaluate systemic inflammatory markers in cases of exogenous endophthalmitis caused by metal foreign bodies after penetrating eye injury and identify risk factors for poor control post-initial emergency surgery.

Methods: Twenty-nine patients with exogenous endophthalmitis underwent emergency surgery with vitrectomy at Xiamen Eye Center (2016-2024). Evaluations included systemic inflammatory markers, microbiology, clinical presentation, treatment strategies, complications, prognostic factors, and visual outcomes.

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Silicone Oil Inhibits Early Bacterial Expansion in an in vitro Model of Intraocular Tamponade.

Ophthalmologica

December 2024

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Introduction: Infectious endophthalmitis, a vision-threatening disease caused by exogenous or endogenous microbial invasion, may require vitrectomy with or without silicone oil (SO) tamponade in severe cases. SO antimicrobial effects have been suggested but not demonstrated in an in vitro environment mimicking real clinical conditions. Using an in vitro intraocular tamponade model, we investigated the antimicrobial activity of SO against 11 bacterial and 1 fungal species, including antibiotic-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae.

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Background: Endophthalmitis is an acute infection of anterior and posterior segment of the eye involving aqueous humour and vitreous cavity along with the other structures. It is classified into many types including bacterial, Fungal, protozoal, viral and atypical forms. Most common route of infection is exogenous either after the surgery or traumatic perforation Objectives were of evaluate the efficacy of intracameral moxifloxacin versus topical moxifloxacin in preventing postoperative acute endophthalmitis after cataract surgery by phacoemulsification.

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Endophthalmitis patients in Makassar City: molecular identification of pathogenic fungal profile.

BMC Infect Dis

November 2024

Department of Microbiology, Faculty of Medicine, Hasanuddin University, Perintis Kemerdekaan No.Km. 10, Tamalanrea Indah, Kec. Tamalanrea, Kota Makassar, Sulawesi Selatan, Makassar, 90245, Indonesia.

Background: Endophthalmitis is a severe inflammation of the internal ocular structures, usually caused by bacterial or fungal infections, and can lead to rapid, irreversible blindness. Fungal endophthalmitis (FE), primarily due to Candida albicans and Aspergillus, is less common than bacterial endophthalmitis but has shown an increase in prevalence over the past two decades. Diagnosing FE is challenging and often delayed due to the time-consuming nature of traditional culture methods.

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Unified Approach to Treating Exogenous Endophthalmitis With Immediate Vitrectomy.

J Vitreoretin Dis

September 2024

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB, Canada.

Article Synopsis
  • A study analyzed the effects and complications of immediate small-gauge pars plana vitrectomy on 107 patients with exogenous endophthalmitis from 2016 to 2022.
  • Results showed significant improvement in best-corrected visual acuity (BCVA) from initial diagnosis to follow-up, with a mean logMAR BCVA change from 2.26 to 1.21.
  • Common complications included retinal detachment (17.8%) and secondary glaucoma (9.3%), highlighting the need for patient counseling on the risks of the surgery.
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