A configurationally stable alkoxy allenyl zinc reagent, en route to anti-anti vicinal amino diols.

Org Lett

Laboratoire de Chimie des Organoéléments, Université Pierre et Marie Curie, 4 place Jussieu 75252 Paris cédex 05, France.

Published: June 2001

AI Article Synopsis

  • An alkoxyallenyl zinc reagent reacts with benzyl imines from lactic and mandelic acids.
  • The reaction exhibits high diastereoselectivity, producing specific stereochemical configurations.
  • The result is the formation of 2-amino-1,3-diol derivatives featuring an anti-anti stereochemical arrangement.

Article Abstract

[see reaction]. The reaction of an alkoxyallenyl zinc reagent with benzyl imines derived from lactic and mandelic acids proceeds highly diastereoselectively and leads to 2-amino-1,3-diol derivatives with an anti-anti pattern.

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Source
http://dx.doi.org/10.1021/ol015941aDOI Listing

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