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Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia.
Respir Res
January 2025
Chiesi Farmaceutici, R&D Department, Parma, Italy.
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity of the strong hyperoxic hit precludes a longer-term follow-up due to high mortality after the first week of life.
View Article and Find Full Text PDFManagement of a Left Anterior Descending Artery Aneurysm in Behçet's Disease: A Case Report.
Mod Rheumatol Case Rep
January 2025
Department of Internal Medicine, King Faisal Specialist Hospital & research center, Jeddah, Saudi Arabia.
Behçet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology that affects blood vessels of all sizes, potentially leading to severe complications such as coronary artery aneurysms. This report describes the case of a 33-year-old woman with BD who presented with recurrent chest pain. Imaging revealed a large saccular aneurysm in the left anterior descending artery.
View Article and Find Full Text PDFChronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development.
Am J Respir Cell Mol Biol
October 2024
The Children's Hospital of Philadelphia, Pediatrics, Philadelphia, Pennsylvania, United States.
Article Synopsis
- * In this study, preterm fetal lambs were subjected to reduced oxygen levels using the EXTEND model, resulting in noticeable growth restrictions and changes in lung structure compared to those with normal oxygen levels.
- * Key findings included fewer blood vessels, increased muscularization in peripheral vessels, enlarged airspaces, and a drop in specific lung cell types and proteins crucial for lung function, indicating that fetal hypoxia mainly affects airway and surfactant production development.
Role of Myeloperoxidase, Oxidative Stress, and Inflammation in Bronchopulmonary Dysplasia.
Antioxidants (Basel)
July 2024
Department of Pediatrics, Medical College of Wisconsin, Suite C410, Children Corporate Center, 999N 92nd Street, Milwaukee, WI 53226, USA.
Bronchopulmonary dysplasia (BPD) is a lung complication of premature births. The leading causes of BPD are oxidative stress (OS) from oxygen treatment, infection or inflammation, and mechanical ventilation. OS activates alveolar myeloid cells with subsequent myeloperoxidase (MPO)-mediated OS.
View Article and Find Full Text PDFSuccessful pregnancy in Takayasu's arteritis type III with complete infrarenal aortic block.
BMJ Case Rep
August 2024
Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
A Gravida 2 Para 1 Live 1 in her late 20s and of South Asian ethnicity with previous lower segment caesarean section (LSCS) was hospitalised for confinement at 37 weeks for chronic hypertension with superimposed pre-eclampsia.The patient was diagnosed with type III Takayasu's arteritis following a previous uncomplicated pregnancy. A year after her first childbirth, she presented with headache, recurrent scleritis, hypertension, bilateral absent lower limb pulses and right femoral bruit.
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