Background: We carried out a descriptive analysis of the mortality in a Catalonian rural town (Canet d'Adri, 12 km from Girona) for the period 1872-1900. The knowledge of the main mortality causes, especially those non-transmissible, could be very illustrative. The objective was to show the distribution of the mortality by age and cause, and to compare mortality due to infections with mortality consequence of the rest of the causes.
Method: Three aspects were analysed: the distribution of the deaths by age and sex; the temporal and seasonal evolution; and the distribution by cause-specific.
Results: 49.3% of the deaths corresponded to women and 50.7% to men. Younger than one-year old were the most important group, 35.6% of the total mortality, followed by older than 65, 23.7%. Respiratory diseases were responsible for 33.4% of deaths; infectious diseases 31.1%, circulatory diseases 13.4% and digestive diseases 2.6%. Amongst younger than 45 year old the main cause of mortality was infectious diseases, above all in women. Respiratory diseases were the main cause of mortality in women older than 45 and in men older than 65 year old. Deaths because circulatory diseases were a very important cause amongst men older than 65.
Conclusions: Besides of the importance of the infectious diseases as the main cause of death, it is surprising the importance of circulatory diseases (the third cause of mortality).
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Bioorg Med Chem
January 2025
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, Bd. Carol 11, 700506 Iasi, Romania. Electronic address:
In the last decades fungal infections became a major threat to human health having an unacceptably occurrence, a high rate of mortality and the number of patients at risk for these infections continue to increase every year. An effective, modern and very useful strategy in antifungal therapy is represented by the use of chimeric and hybrid drugs, most of them being with azaheterocycle skeleton. In this review, we present an overview from the last five years of the most representative achievements in the field of chimeric and hybrid diazine derivatives with antifungal properties.
View Article and Find Full Text PDFPrehosp Disaster Med
January 2025
Department of Pediatric Emergency Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Background: Drowning persists as a preventable pediatric cause of severe morbidity and mortality. This study aims to investigate the risk factors, circumstances, and medical consequences associated with pediatric drowning incidents in order to identify patterns that can inform targeted interventions.
Methods: This was a retrospective analysis of a cohort of pediatric drowning cases.
J Am Heart Assoc
January 2025
Monash Heart Victorian Heart Hospital, Monash Health Melbourne Australia.
Background: Preprocedural fasting is widely used before percutaneous coronary intervention (PCI). However, the incidence of procedural intubation during PCI is unknown. This study aims to identify the incidence and predictors for procedural intubation during PCI.
View Article and Find Full Text PDFJ Pathol Clin Res
January 2025
Department of Urology, University of Duisburg-Essen, Essen, Germany.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression-based Lund Taxonomy.
View Article and Find Full Text PDFCrit Care Resusc
December 2024
Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Objective: To describe the six-month functional outcomes of patients who received extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest (IHCA) in Australia.
Design: Secondary analysis of EXCEL registry data.
Setting: EXCEL is a high-quality, prospective, binational registry including adult patients who receive extracorporeal membrane oxygenation (ECMO) in Australia and New Zealand.
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