Collagens and proteoglycans are the main components of connective tissue. Prolidase plays an important role in the balance between collagen biosynthesis and degradation and its activity reflects the rate of collage turn-over. The activity of this enzyme is known to be regulated by interaction of collagen with beta 1 integrin receptor. It was found that increase in the uterine leiomyoma weight is accompanied by increased beta 1 integrin receptor expression and prolidase activity. It suggests that collagen turn-over is altered in uterine leiomyoma growth.
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