Ionic currents responsible for excitability of retinal ganglion cells (RGC) freshly isolated from eyes of adult rats were studied. Kutward potassium currents in RGC represented by populations of slow inactivating and non-inactivating currents. Inward sodium currents were completely blocked by extracellular application of 0.25 mM TTX. Calcium conductance in freshly isolated RGC has two components: low- and high-threshold. Extracellular application of nifedipine (10 mM) or Cd2+ (10 mM) blocked high threshold calcium currents by 28% and 60%, correspondingly, without any significant effect on low threshold calcium currents.
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