The "sensory" circumventricular organs, with their leaky blood-brain barriers, permit contact between brain neurons and blood-borne molecules. Body fluid balance and cardiovascular control involve established interface functions of subfornical organs. Their recently identified target functions for hormones released during digestion suggest that they may coordinate fluid and food intake.
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University of Manitoba, Department of Biological Sciences, Winnipeg, MB, Canada, R3X0B5. Electronic address:
The subfornical organ (SFO) is a sensory circumventricular organ of the central nervous system and plays a key role in regulation of a number of homeostatic processes because of its ability to detect and respond to circulating signals and communication to homeostatic control centres. A previous study reported a change in expression of 687 transcripts in rat SFO following a 48h fast; of particular interest was the observed downregulation of the transcript encoding the Nav1.3 voltage-gated Na channel.
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