Vertebrate sound-producing muscles can contract at frequencies greater than 100 Hz, a feat impossible in locomotory muscles. This is not accomplished by unique proteins or structures but by qualitative shifts in isoforms and quantitative reapportionment of structures. Speed comes with costs and trade-offs, however, that restrict how a muscle can be used.
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http://dx.doi.org/10.1152/physiologyonline.1998.13.6.261 | DOI Listing |
J Biomol Struct Dyn
December 2024
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Selective inhibition of histone deacetylase 8 (HDAC8) has emerged as a promising approach for treating various diseases, including cancer. However, finding key structural features for HDAC8 inhibition and developing effective and selective HDAC8 inhibitors (HDAC8s) pose significant challenges. In the past few years, the development of various scaffolds for inhibiting HDAC8 has significantly risen and the quest continues.
View Article and Find Full Text PDFMaterials (Basel)
November 2024
Institute of Civil Engineering, Warsaw University of Life Sciences-SGGW, 166 Nowoursynowska Street, 02-787 Warsaw, Poland.
Nowadays, much of the attention paid to building construction is focused on sustainability and environmental protection. The materials applied in construction should be safe and free of toxins, but they should also follow the idea of circular construction. Quests for materials with an appropriate structure and composition, unifying features of a construction, insulation (thermally and acoustically), and environmentally friendly material turned our attention in this paper toward expanded perlite (EP).
View Article and Find Full Text PDFSci Rep
November 2024
Dalio Institute of Cardiovascular Imaging, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Extended reality (XR) technologies are emerging as promising platforms for medical training and procedural guidance, particularly in complex cardiac interventions. This paper presents a high-fidelity methodology to perform real-time 3D catheter tracking and visualization during simulated cardiac interventions. A custom 3D-printed setup with mounted cameras enables biplane video capture of a catheter.
View Article and Find Full Text PDFJ Environ Manage
December 2024
School of Information Management, Wuhan University, Wuhan, 430072, China; Center for Studies of Information Resources, Wuhan University, Wuhan, 430072, China; Big Data Institute, Wuhan University, Wuhan, 430072, China. Electronic address:
To achieve the ambitious carbon neutrality goal by 2060, the Chinese government has implemented a series of carbon neutrality policies. These policy documents are pivotal in facilitating the examination of policy substance, the scrutiny of policy evolution, and the dissection of the policy instruments involved. This study develops an analytical framework for assessing carbon neutrality through policy documents, applying text mining and network analysis to probe the intricacies of policy topics, interagency collaboration, and diffusion dynamics.
View Article and Find Full Text PDFPhys Rev E
September 2024
Department of Physics, Indian Institute of Technology Tirupati, Tirupati 517619, India.
In the classical context, it is well known that, sometimes, if a search does not find its target, it is better to start the process anew. This is known as resetting. The quantum counterpart of resetting also indicates speeding up the detection process by eliminating the dark states, i.
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