Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directed gene transfer (called AAV2/5). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly, we saw no immunologic evidence of previous exposure to AAV5 capsids in a large population of healthy human subjects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC114336 | PMC |
| http://dx.doi.org/10.1128/JVI.75.13.6199-6203.2001 | DOI Listing |
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