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Challenges in the Diagnosis and Management of Immune Complex-Mediated Membranoproliferative Glomerulonephritis and Complement 3 Glomerulopathy.
Kidney Int Rep
January 2025
Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) and complement 3 glomerulopathy (C3G) are rare, complement-mediated kidney diseases, previously classified under the group of kidney disorders termed membranoproliferative glomerulonephritis (MPGN) type 1, type 2, and type 3. Despite new advances in our understanding of IC-MPGN and C3G, several unmet needs persist in the diagnosis and management of patients with these nephropathies, due in part to their rarity and their overlapping clinical presentations, histologic features, and underlying pathophysiologies. This review summarizes our current understanding of the role of complement in IC-MPGN and C3G, and underlines the key histopathologic differences between the diseases.
View Article and Find Full Text PDFArticle Synopsis
- Membranous proliferative glomerulonephritis (MPGN) is a rare kidney condition characterized by specific pathological changes, observed in a 77-year-old man with mild proteinuria and hematuria.
- Laboratory tests indicated elevated MPO-ANCA levels and a renal biopsy showed distinct features that confirmed MPGN type 3.
- The patient responded well to treatment with an SGLT2 inhibitor and the case raises questions about the association between high MPO-ANCA levels and latent tuberculosis infection, suggesting a potential link that needs further investigation.*
Case report: membranoproliferative glomerulonephritis associated with Q fever causing chronic endocarditis.
BMC Nephrol
September 2024
Department of Internal Medicine and Nephrology, Herz-Jesu-Krankenhaus Münster-Hiltrup, Münster-Hiltrup, Germany.
Background: Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections.
Case Presentation: We herein present the case of a 62-year-old male patient who presented with fatigue and was found to have severe anemia, impaired renal function, and nephrotic syndrome. A renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) of the immune complex type with activation of the classical complement pathway.
Histopathologic Characteristics of Childhood Nephrotic Syndrome in a Tertiary Health Facility in Nigeria.
West Afr J Med
May 2024
Department of Paediatrics, Federal Teaching Hospital, Katsina.
Background: Globally, the predominant histopathologic characteristic of childhood nephrotic syndrome has been minimal change nephropathy (MCN). However, some studies from Africa and Nigeria have revealed otherwise. It is imperative that this pattern is re-examined from time to time given changing disease and environmental dynamics from place to place.
View Article and Find Full Text PDFParaneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge.
J Hematop
December 2024
Department of Hematology and Hemotherapy, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Mantle cell lymphoma (MCL) is a rare and aggressive type of lymphoma that can affect the kidneys. The disease can lead to kidney impairment, and glomerulonephritis (GN) is a rare but serious complication of MCL. We report a case of MCL with kidney interstitial infiltration and membranoproliferative glomerulonephritis with focal and segmental glomerulosclerosis.
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