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Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights.
Cytotherapy
November 2024
Department of Translational and Precision Medicine, University of Rome, Rome, Italy. Electronic address:
Cellular and gene therapy (CGT) products have emerged as a popular approach in regenerative medicine, showing promise in treating various pancreatic and liver diseases in numerous clinical trials. Before these therapies can be tested in human clinical trials, it is essential to evaluate their safety and efficacy in relevant animal models. Such preclinical testing is often required to obtain regulatory approval for investigational new drugs.
View Article and Find Full Text PDFAthlete Selective Androgen Receptor Modulators Abuse: A Systematic Review.
Am J Sports Med
January 2025
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Background: Selective androgen receptor modulators (SARMs) are small-molecule compounds that exert agonist and antagonist effects on androgen receptors in a tissue-specific fashion. Because of their performance-enhancing implications, SARMs are increasingly abused by athletes. To date, SARMs have no Food and Drug Administration approved use, and recent case reports associate the use of SARMs with deleterious effects such as drug-induced liver injury, myocarditis, and tendon rupture.
View Article and Find Full Text PDFApplication of biomass carbon dots in food packaging.
Environ Sci Pollut Res Int
January 2025
College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Since its discovery, carbon quantum dots (CDs) have been widely applied in cell imaging, drug delivery, biosensing, and photocatalysis due to their excellent water solubility, chemical stability, fluorescence stability biocompatibility, low toxicity, and preparation cost. However, the low fluorescence yield and poor surface structure limit the application of CDs. Heteroatom doping is considered an ideal method to improve CDs' optical and electrical properties.
View Article and Find Full Text PDFEffect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron.
Acta Vet Scand
January 2025
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 2, 1870, Frederiksberg C, Denmark.
Background: Prevention of iron deficiency in suckling piglets by intramuscular injection of a standardized amount of iron dextran or gleptoferron in the first days of life can lead to over- or underdosage with respective health risks. Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible.
View Article and Find Full Text PDFIonically crosslinked composite gels containing amine-functionalized CoFeO nanoparticles as a bioactive and pH-responsive drug delivery system.
Int J Biol Macromol
January 2025
Department of Chemistry, Sri Krishnadevaraya University, Ananthapur 515003, India. Electronic address:
Composite gels are a type of soft matter, which contains a continuous three-dimensional crosslinked network and has been embedded with non-gel materials. Compared to pure gels, composite gels show high flexibility and tunability in properties and hence have attracted extensive interest in applications ranging from cancer therapy to tissue engineering. In this study, we incorporated triethylenetetramine (TETA)-functionalized cobalt ferrite nanoparticles (ANPs) into a hydrogel consisting of sodium alginate (SA) and methyl cellulose (MC), and examined the resulting composite gels for controlled drug release.
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