Chromosomal translocation 3;22 in an infertile man.

Objective: To present the first case of an infertile male with a normal phenotype and chromosomal translocation 3;22.

Design: Case report.

Setting: POVISA Medical Center.

Patient(s): A 45-year-old man with primary infertility for 13 years and with different partners; the patient has a family history of recurrent miscarriages and low fertility.

Intervention(s): Lymphocytic karyotype and electron microscopy.

Main Outcome Measure(s): Physical examination and semen analysis.

Result(s): The semen analysis revealed oligoasthenoteratospermia. The lymphocytic karyotype detected a translocation 3;22, and electron microscopy showed a lack of the central microtubule pair and peripheral doublet.

Conclusion(s): An association between translocation 3;22 and other abnormalities in infertile males has been reported, but no such association has ever been described in men whose only clinical manifestation is infertility.