AI Article Synopsis
- The expression of proteases plays a crucial role in enabling tumors to become invasive and metastatic during cancer progression.
- The interaction between stromal cells and cancer cells regulates the production of important proteases, like metalloproteinases and serine proteinases.
- Surprisingly, higher levels of protease inhibitors are linked to worse survival outcomes in cancer patients, indicating that their role in tumor progression is more complex than previously thought.
Article Abstract
Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially.
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