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Adjuvant Cytotoxic Chemotherapy may not be Associated with a Survival Advantage for Resected Intrahepatic Cholangiocarcinoma.
Ann Surg Oncol
January 2025
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Background: Randomized data suggest improved survival with adjuvant chemotherapy for biliary tract cancers; however, subset analyses of intrahepatic cholangiocarcinoma (IHC) show limited survival benefit. This study evaluated the impact of adjuvant chemotherapy on recurrence patterns and overall survival (OS) in patients with resected IHC.
Methods: Patients who underwent curative-intent resection for IHC were identified within a bi-institutional dataset and the National Cancer Database (NCDB).
Using Video-Reflexive Methods to Develop a Provider Down Protocol for the New South Wales Biocontainment Center.
Health Secur
September 2024
Gwendolyn L. Gilbert, MD, FRACP, FRCPA, M. Bioethics, FASM, is a Senior Researcher at the Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
The New South Wales Biocontainment Centre is a statewide referral facility for patients with high-consequence infectious disease (HCID). The facility collaborates with researchers to adapt existing HCID procedures such as donning and doffing of personal protective equipment (PPE). However, information on how to respond safely to collapse of a healthcare provider in full PPE within a contaminated zone is scarce.
View Article and Find Full Text PDFDeformation under flow and morphological recovery of cancer cells.
Lab Chip
August 2024
Laboratoire Interdisciplinaire des Energies de Demain, CNRS UMR 8236, Université Paris Cité, F-75013, Paris, France.
The metastatic cascade includes a blood circulation step for cells detached from the primary tumor. This stage involves significant shear stress as well as large and fast deformation as the cells circulate through the microvasculature. These mechanical stimuli are well reproduced in microfluidic devices.
View Article and Find Full Text PDFManaging greenhouse gas emissions in the terminal year of life in an overwhelmed health system: a paradigm shift for people and our planet.
Lancet Planet Health
May 2024
Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.
Article Synopsis
- Health care is responsible for 4.4% of global carbon emissions, largely due to high resource use in hospitals, particularly during a patient's last year of life.
- In this crucial period, health care demands rise sharply, leading to increased emissions that often conflict with patients' preferences for care.
- Suggested solutions include improving advanced care planning, initiating palliative care sooner, reducing unnecessary medication prescriptions, and increasing access to community care options, with findings primarily based on Canadian data but relevant to other wealthy nations.
Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study.
EClinicalMedicine
April 2024
University of Bordeaux, National Institute for Health and Medical Research (INSERM) U1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux, France.
Article Synopsis
- Childhood tuberculosis (TB) is often underdiagnosed due to low awareness and limited access to necessary diagnostic tools in healthcare settings.
- An operational research study in several African and Asian countries tested a comprehensive diagnostic approach by decentralizing TB diagnostics to district hospitals and primary health centers for children under 15 years old.
- The intervention significantly increased TB detection rates, with diagnoses rising from 0.08% pre-intervention to 0.23% during the intervention, highlighting the effectiveness of decentralized health services.
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