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Chronic Fructose and Sucrose Intake and 24-Hour Urine Composition.

Kidney360

August 2024

Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

Key Points: Higher dietary intakes of fructose and sucrose are associated with lower 24-hour urine calcium. Higher dietary intakes of fructose and sucrose are associated with other modest changes in 24-hour urine composition.

Background: Consumption of sugar, including fructose and sucrose, is associated with higher risk of kidney stones.

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Fructose bisphosphate aldolases (FBAs) catalyze the reversible cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. We analyzed two previously uncharacterized cytosolic Arabidopsis FBAs, AtFBA4 and AtFBA5. Based on a recent report, we examined the interaction of AtFBA4 with calmodulin (CaM)-like protein 11 (AtCML11).

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