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Fascin structural plasticity mediates flexible actin bundle construction.
Nat Struct Mol Biol
January 2025
Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Fascin cross-links actin filaments (F-actin) into bundles that support tubular membrane protrusions including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration during metastasis, and fascin inhibitors are under development as cancer therapeutics. Here, we use cryo-EM, cryo-electron tomography coupled with custom denoising and computational modeling to probe human fascin-1's F-actin cross-linking mechanisms across spatial scales.
View Article and Find Full Text PDFMyeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis.
Front Immunol
January 2025
Department of Stomatology, The People's Hospital of Deyang City, Deyang, Sichuan, China.
Background: Periodontal disease is a widespread inflammatory condition that compromises the supporting structures of the teeth, potentially resulting in tooth loss if left untreated. Despite advancements in therapeutic interventions and an enhanced understanding of its pathophysiology, emerging techniques such as single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) present new opportunities for precision medicine in the management of periodontal disease.
Methods: Data derived from the GSE152042 dataset underwent rigorous quality control, normalization, and dimensionality reduction using Seurat and the MonacoImmuneData framework.
Assays of Platelet SNARE-actin Interactions.
Methods Mol Biol
January 2025
Division of Hemostasis and Thrombosis, Department of Medicine, BIDMC, Harvard Medical School, Boston, MA, USA.
The actin cytoskeleton serves an important, but poorly characterized, role in controlling granule exocytosis. The dynamic nature of actin remodeling allows it to act both as a barrier to prevent indiscriminate granule release and as a facilitator of membrane fusion. In its capacity to promote exocytosis, filamentous actin binds to components of the exocytotic machinery through actin binding proteins, but also through direct interactions with SNAREs.
View Article and Find Full Text PDFBioinformatic Analysis of Actin-Binding Proteins in the Nucleolus During Heat Shock.
Genes (Basel)
December 2024
Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe 650-0047, Japan.
Background/objectives: Actin plays a crucial role not only in the cytoplasm, but also in the nucleus, influencing various cellular behaviors, including cell migration and gene expression. Recent studies reveal that nuclear actin dynamics is altered by cellular stresses, such as DNA damage; however, the effect of heat shock on nuclear actin dynamics, particularly in the nucleolus, remains unclear. This study aims to elucidate the contribution of nucleolar actin to cellular responses under heat shock conditions.
View Article and Find Full Text PDFFrom Molecules to Amoeboid Movement: A New Way for Understanding the Morphology Through Actin-Binding Proteins.
Biomolecules
December 2024
Zoological Institute RAS, St. Petersburg 199034, Russia.
Amoebozoa is a group of single-celled organisms that change their shape during locomotion. However, there is a taxon-specific complex of morphological characters inherent in the moving amoebae, known as locomotive forms. Actin is one of the proteins most important for amoeboid movement that, together with actin-binding proteins, construct the architecture of the cytoskeleton in the amoeboid cells.
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