The authors discuss the need for international standards for the microbiologic and genetic quality of rodents.
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The advisory body on animal ethics of a global pharmaceutical company: A global organization to address ethical and societal concerns about animal use.
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How do you promote ethical principles on a global scale regarding the use of animals for scientific purposes within a global pharmaceutical company like Sanofi? In 2017, the Advisory Body on Animal Ethics (ABAE) was created to harmonize animal ethics across all Sanofi sites. As an advisory body to the Bioethics Committee, the ABAE addresses societal concerns related to the use of animals and develops corporate policies on critical topics. Its composition, objectives and operating processes are described, along with the results achieved.
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Ethanol, a bioactive compound prevalent in both social and industrial applications, is present in alcoholic beverages as well as a range of everyday products. In food, ethanol functions primarily as an additive or a by-product of fermentation, while in pharmaceuticals and cosmetics, it serves as a solvent or preservative. Despite its widespread use, three critical research gaps exist in current literature.
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In alignment with the global movement toward reducing animal testing, several reconstructed human epidermis (RHE) models have been created for conducting skin irritation tests. These models have undergone development, verification, validation, and integration into OECD TG 439. Our team has introduced a novel in-house RHE named GB-RHE, and we adhere to OECD TG 439 to pre-validate the model and test its potential employment for nanoparticle irritation studies.
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Faculty of Education, Health and Human Sciences, University of Greenwich, London, United Kingdom.
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