This paper describes the continuation of an investigation into the effects of increased flow on the dissolved oxygen concentration in the River Maun, UK. A previous investigation indicated that an oxygen demand additional to that in the water phase is observed during and directly after intermittent discharges. Simplified modelling of the river indicated that the additional oxygen demand was possibly linked to the disturbance of sediment during such events. A device has been developed which can be used in situ to measure the effect of flow velocity (shear stress) on the additional demand. Preliminary tests have shown that the inferred demand is significant. It is proposed that the in situ device now be used to measure the oxygen demand of the bed material at a number of locations and flow speeds and that a relationship between the additional demand and velocity be established, with the aim of incorporating such a relationship into a simplified model.
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J Environ Sci Health A Tox Hazard Subst Environ Eng
January 2025
School of Environmental Engineering, Faculty of Environmental and Safety Engineering, Qingdao University of Science and Technology, Qingdao, China.
Two-chamber microbial fuel cell (MFC) with biogas slurry (BS) of corn stover as the anode substrate and as the cathode substrate was investigated to solve the problem of the accumulation of wastewater generated from biogas plants and to achieve low-cost separation of CO from biogas. A simple two-compartment MFC was constructed using biocatalysis and inexpensive materials without expensive catalysts. The performance of MFC (X1-W, Y1-W, Z1-W) with different biogas solution concentrations as anode substrate and MFC (X2-C, Y2-C, Z2-C) with as biocathode were compared, respectively.
View Article and Find Full Text PDFCommun Biol
January 2025
School of Psychology and Sussex Neuroscience, University of Sussex, Brighton, UK.
Reduced cerebral blood flow occurs early in the development of Alzheimer's disease (AD), but the factors producing this reduction are unknown. Here, we ask whether genetic and lifestyle risk factors for AD-the ε4 allele of the Apolipoprotein (APOE) gene, and physical activity-can together produce this reduction in cerebral blood flow which leads eventually to AD. Using in vivo two-photon microscopy and haemodynamic measures, we record neurovascular function from the visual cortex of physically active or sedentary mice expressing APOE3 and APOE4 in place of murine APOE.
View Article and Find Full Text PDFJ Control Release
January 2025
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:
Osteoarthritis is the most prevalent form of arthritis, and a leading cause of pain and long-term disability. Dysregulation of redox homeostasis is a key feature in the pathological progression of osteoarthritis that amplifies the inflammatory response, aggravates synovitis and accelerates cartilage degradation. Herein, a hemin and chitosan-mediated antioxidant gel inducing ROS conversion (hc-MAGIC) was constructed to targeting oxidative stress for osteoarthritis treatment.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
Increasing evidence has highlighted the effects of biodegradable microplastics (MPs) on soil organic matter (SOM), but the role of soil type and incubation time remains unclear. This study investigated the effects of polylactic acid microplastics (PLA-MPs) on the amount and molecular composition of dissolved organic matter (DOM) across three paddy soil types (Ferralsol, Alfisol, and Mollisol) and incubation times, revealing soil-specific patterns in DOM transformation: PLA-MPs reduced DOM content in Ferralsol and Alfisol by 29.3-68.
View Article and Find Full Text PDFJ Med Microbiol
January 2025
Department of Stem Cell and Regenerative Medicine, Medical Biotechnology, Centre for Interdisciplinary Research, D.Y. Patil Education Society (Deemed to be University), Kolhapur- 416-003, Maharashtra, India.
Increased virulence and drug resistance in species of resulted in reduced disease control and further demand the development of potent antifungal drugs. The repurposing of non-antifungal drugs and combination therapy has become an attractive alternative to counter the emerging drug resistance and toxicity of existing antifungal drugs against and non-albicans species. This study aimed to accelerate antifungal drug development process by drug repurposing approach.
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