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Technical Note on Modified Direct Intrahepatic Portocaval Shunt Targeting Different Vessels for Portal Vein Obstruction in Cirrhosis.
Cardiovasc Intervent Radiol
January 2025
Department of Gastroenterology and Hepatology, Zhongnan Hospital of Wuhan University, No. 169, Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China.
Purpose: This study aimed to explore a modified direct intrahepatic portocaval shunt (DIPS) technique as an alternative approach for patients with portal vein occlusion (PVO) and cirrhosis who were not candidates for traditional transjugular intrahepatic portosystemic shunt (TIPS) due to anatomical challenges.
Technique: Three patients with esophageal or gastric fundus variceal hemorrhage complicated by severe PVO were treated using innovative DIPS approaches. Preoperative contrast-enhanced computed tomography was employed to assess anatomical feasibility.
Portocaval shunts' role in gut microbiota and hepatic encephalopathy: The gut-to-brain pathway.
World J Gastroenterol
November 2024
Department of Gastroenterology, Istanbul Medipol University Sefakoy Health Practice Research Center, İstanbul 38000, Türkiye.
I read the study by Zhao with great interest. Although the study design was quite complicated, it was successful in raising awareness of science and relevant researchers. Thirty patients with liver cirrhosis and portal hypertension secondary to chronic hepatitis B were included in the study.
View Article and Find Full Text PDFEditorial on "Complex Hepatectomy Under Total Vascular Exclusion of the Liver Preserving the Caval Flow with Portal Hypothermic Perfusion and Temporary Porta-Caval Shunt: A Proof of Concept".
Ann Surg Oncol
October 2024
Ajmera Transplant Program and HPB Surgical Oncology, Toronto General Hospital, University of Toronto, Toronto, Canada.
Identifying the optimal measurement timing and hemodynamic targets of portal pressure gradient after TIPS in patients with cirrhosis and variceal bleeding.
J Hepatol
August 2024
Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Centre for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China; Department of Liver Diseases and Digestive Interventional Radiology, Digestive Diseases Hospital, Xi'an International Medical Center Hospital, Northwest University, Xi'an 710032, China. Electronic address:
Article Synopsis
- The study investigates the best timing and target for measuring portacaval pressure gradient (PPG) in patients who have undergone transjugular intrahepatic portosystemic shunt (TIPS) for variceal bleeding.
- Researchers analyzed data from 466 patients, measuring PPG at three time points: immediately after, 24-72 hours post, and one month after TIPS placement.
- Findings indicate that PPG measured 24-72 hours after TIPS is more predictive of long-term outcomes, with an optimal target range of 11-14 mmHg linked to reduced risk of complications like hepatic encephalopathy.
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist.
Metab Brain Dis
October 2024
Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad, No. 940, Ciudad Universitaria, C.P. 20100, Aguascalientes, Aguascalientes, México.
Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute liver failure or chronic liver injury. Liver dysfunction impairs ammonia detoxification, allowing it to cross the blood-brain barrier (BBB) and disrupt brain function. The hippocampus becomes a crucial target during elevated ammonia levels, causing spatial memory impairment and decreased learning ability.
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