Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.

Bioorg Med Chem Lett

Medicinal Chemistry, Aventis Pharma, 102 route de Noisy, F-93235 Cedex, Romainville, France.

Published: June 2001

A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation constant of the resulting compounds. Antibacterial activity of the new coumarin derivatives could be correlated with the amount of uncharged form in physiological conditions.

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http://dx.doi.org/10.1016/s0960-894x(01)00257-8DOI Listing

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