Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(01)00214-1 | DOI Listing |
Publication Analysis
Top Keywords
synthesis hydrolytic
4
hydrolytic stability
4
stability studies
4
studies albendazole
4
albendazole carrier
4
carrier prodrugs
4
prodrugs three
4
three n-acyl
4
n-acyl n-alkoxycarbonyl
4
n-alkoxycarbonyl n-acyloxymethyl
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!