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Indications and outcomes of pediatric high flow nasal cannula use in the home setting.
J Hosp Med
December 2024
Complex Care Program, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Objective: To describe the patient characteristics, indications, and clinical outcomes of home high flow nasal cannula (HFNC) among pediatric patients. To evaluate secular trends in home HFNC initiation between 2013 and 2022.
Methods: A retrospective review of all children on home HFNC between 2013 and 2023 was conducted at a tertiary care pediatric hospital in Ontario, Canada.
Differential neuromotor control of the vertical and longitudinal genioglossus muscle fibers: An overlooked tongue retractor.
Respir Physiol Neurobiol
January 2025
Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel; Respiratory Unit, Bnai-Zion Medical Center, Haifa, Israel. Electronic address:
Article Synopsis
- The study investigates the role of the genioglossus (GG) muscle in tongue movement during breathing, specifically focusing on the anterior fibers and their EMG activity during wakefulness and sleep.
- Results showed that electrical stimulation of the anterior GG fibers caused tongue retraction, while the longitudinal fibers were responsible for protrusion.
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Enhancing Lung Recellularization with Mesenchymal Stem Cells via Photobiomodulation Therapy: Insights into Cytokine Modulation and Sterilization.
Int J Mol Sci
September 2024
School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-220, SP, Brazil.
Article Synopsis
- Lung transplantation is often necessary for severe lung diseases, but the success rates are low, making lung bioengineering a potential alternative using decellularized lung extracellular matrix (ECM).
- The study focused on improving lung recellularization by seeding decellularized lungs with mesenchymal stem cells and applying photobiomodulation therapy (PBMT) at two different wavelengths (660 nm for recellularization and 880 nm for sterilization).
- Results showed that PBMT helped maintain important structural components of the lungs and modulated pro-inflammatory cytokines, indicating its potential to enhance therapeutic strategies in lung bioengineering.
Background: The current standard treatment for obstructive sleep apnea (OSA), continuous positive airway pressure (CPAP), is characterized by a low adherence rate due to various factors including circuit-dependent carbon dioxide (CO) rebreathing, which can exacerbated by disparate factors, such as low PAP, use of auto-titrating PAP or ramps. However, risk factors for rebreathing are often overlooked or poorly understood in clinical practice. Therefore, our objective was to evaluate the extent of rebreathing occurring with commonly used CPAP masks across varying PAPs, tidal volumes, and respiratory rates.
View Article and Find Full Text PDFEffect of continuous positive airway pressure helmet on respiratory function following surgical procedures in brachycephalic dogs: A randomized controlled trial.
Vet Surg
July 2024
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Objective: To evaluate the effect of continuous positive airway pressure (CPAP) on respiratory function in the early postoperative period of brachycephalic dogs.
Study Design: Prospective, randomized clinical trial.
Animals: A total of 32 dogs.
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