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[Addison's disease: looking to the past and the future].
Rev Med Liege
January 2025
Service d'Endocrinologie, CHU Liège, Belgique.
In 1849, Thomas Addison discovered alterations in the adrenal glands at autopsy of three patients who had died with idiopathic anemia. Struck by Addison's work, Charles-Edouard Brown-Séquard demonstrated in 1851 that bilateral adrenalectomy in dogs was fatal. It was not until 1950 that the discovery of the hormones of the adrenal cortex, their structure and their biological effects allowed Kendall, Reichstein and Hench to win the Nobel Prize in Physiology or Medicine.
View Article and Find Full Text PDFSimilar Kinetics of Pulmonary SARS-CoV-2 Load in Intensive Care Unit Patients with COVID-19 Pneumonia with or Without Autoantibodies Neutralizing Type I Interferons.
J Clin Immunol
November 2024
Médecine Intensive Réanimation, Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France.
Purpose: The pathogenesis of life-threatening coronavirus disease 2019 (COVID-19) pneumonia in ICU patients can involve pre-existing auto-antibodies (auto-Abs) neutralizing type I interferons (IFNs). The impact of these auto-Abs on SARS-CoV-2 clearance in the lower respiratory tract (LRT) is unclear.
Methods: We performed a retrospective study in 99 ICU patients with COVID-19 pneumonia between March and May 2020.
Fever following extracorporeal membrane oxygenation decannulation: Infection, thrombosis or just physiology?
J Crit Care
February 2025
Sorbonne Université, Service de Médecine Intensive Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, France; INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France. Electronic address:
Purpose: Fever is frequent after extracorporeal membrane oxygenation (ECMO) decannulation. We aimed to evaluate the incidence of post-decannulation fever and describe its causes.
Methods: Adult ECMO patients who were successfully weaned from ECMO were retrospectively included.
Herpes simplex virus and cytomegalovirus lung reactivations in severe COVID-19 patients: to treat or not to treat? That is (still) the question.
Intensive Care Med
August 2024
CHRC, NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056, Lisbon, Portugal.
Clinical characteristics associated with functioning trajectories following admission to a psychiatric institution: A prospective cohort study of individuals with psychosis.
Psychiatry Res
September 2024
Department of Psychiatry and Addictology, Faculty of Medicine, University of Montreal. Montreal, QC, Canada; Research center of the Institut universitaire en santé mentale de Montréal. Montreal, QC, Canada; Services et recherche psychiatrique AD. Montreal, QC, Canada; Institut national de psychiatrie légale Philippe-Pinel. Montreal, QC, Canada. Electronic address:
Article Synopsis
- Psychotic disorders can hinder recovery, making functional improvement challenging after hospitalization, which is a critical time for intervention.
- A study analyzed 453 individuals with acute psychosis over a year to explore factors affecting functional recovery, identifying three groups: “improving,” “stable,” and “worsening” function.
- Notably, those starting with more severe symptoms tended to improve function over time, and while the "improving" and "stable" groups showed lasting psychiatric symptoms improvements, the "worsening" group’s initial gains did not sustain.
- These findings suggest that focusing on functional recovery is crucial, rather than just preventing relapses.
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