Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00003246-200104000-00046 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment.
Lipids Health Dis
January 2025
Emergency surgery Dapartment (Trauma center), The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471003, Henan, China.
Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function.
View Article and Find Full Text PDFCervical Cancer Cells Use the CD95 and IL-2 Pathways to Promote Their Proliferation and Survival.
Biomolecules
December 2024
Molecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, UMIEZ Campus II FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico.
Cervical cancer is a global health problem; therapies focused on eliminating tumour cells and strengthening different immunotherapies are in development. However, it has been observed that cervical tumour cells can evade cell death mechanisms and generate immune system molecules to promote their proliferation and metastasis. In this context, we analysed the role of the IL-2 and CD95 pathways, essential molecules in activating the immune system and eliminating tumour cells.
View Article and Find Full Text PDFAging Oocytes: Exploring Apoptosis and Its Impact on Embryonic Development in Common Carp (Cyprinus carpio).
J Anim Sci
January 2025
Research Institute of Fish Culture and Hydrobiology, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodňany 389 01, Czech Republic.
Article Synopsis
- Ovulation, fertilization, and embryo development are critical processes whose success is compromised by post-ovulatory aging, leading to reduced oocyte quality and fertilization ability.
- The study focused on common carp and found that oocyte aging significantly triggers apoptosis, particularly noticeable after 48 hours post-stripping, with increased levels of pro-apoptotic genes and active caspase 3 enzyme.
- Although early blastula embryos (5 HPF) from both fresh and aged oocytes showed no signs of apoptosis, the embryos from aged oocytes at 24 HPF displayed heightened apoptosis, indicating a time-dependent effect of oocyte aging on embryonic development.
Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors.
J Immunother Cancer
January 2025
Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Background: Immune checkpoint inhibitors (ICIs) are recommended to treat patients with deficient mismatch repair/microsatellite instability high (dMMR/MSI-H) metastatic colorectal cancer (mCRC). Pivotal trials have fixed a maximum ICI duration of 2 years, without a compelling rationale. A shorter treatment duration has the potential to improve patients' quality of life and reduce both toxicity and cost without compromising efficacy.
View Article and Find Full Text PDFFADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel.
Fish Shellfish Immunol
January 2025
Jimei University, College of Fisheries, Key Laboratory of Healthy Mariculture for the East China Sea, Xiamen, 361021, China; Jimei University, College of Fisheries, Engineering Research Center of the Modern Technology for Eel Industry, Xiamen, 361021, China. Electronic address:
Fas-associated protein with Death Domain (FADD) is a crucial signaling component of apoptosis and a vital immunomodulator on inflammatory signaling pathways. However, information on FADD-mediated apoptosis and immune regulation is limited in teleost. We herein cloned a FADD homolog, AjFADD, from Japanese eel (Anguilla japonica).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!