Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Synergistic Effects of Anti-echinococcosis Drug Candidates Combined With Atovaquone in Culture Assays and Mice With Primary Infections of Echinococcus multilocularis.
Cureus
November 2024
Department of Pediatrics, Teikyo University School of Medicine, Tokyo, JPN.
Background Alveolar echinococcosis (AE) is a fatal zoonotic disease distributed mainly in the Northern Hemisphere. At present, its curative treatment relies on surgery, and the development of effective drugs is needed. We previously demonstrated the anti-echinococcal effect of atovaquone (ATV) as a mitochondrial complex III inhibitor in both in vitro and in vivo experiments.
View Article and Find Full Text PDFRare Presentation of Echinococcal Disease: A Systematic Review on Arterial Hydatid Cyst.
Ann Vasc Surg
December 2024
Unit of Vascular Surgery, Department of Cardiovascular and Pulmonary Sciences - Università Cattolica del Sacro Cuore, Rome, Italy; Unit of Vascular Surgery, Department of Cardiovascular Sciences - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Article Synopsis
- Echinococcosis is a rare but serious parasitic disease primarily affecting the liver and lungs, with arterial echinococcosis posing significant health risks, yet its management and outcomes are not well-documented.
- Researchers conducted a thorough review of literature and identified 32 cases, revealing that most patients experience chronic pain, with the majority requiring surgical removal of cysts and antiparasitic treatment, predominantly using albendazole.
- While most patients had good outcomes post-surgery, the condition remains dangerous, highlighting the need for further investigation into effective treatment strategies and patient management.
Presentation and management of pancreatic hydatid cyst: A comprehensive systematic review of the literature with meta-data.
Pancreatology
November 2024
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, 46001, Kurdistan, Iraq; Kscien Organization for Scientific Research, Hamid Street, Azadi Mall, Sulaymaniyah, 46001, Kurdistan, Iraq; College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, 46001, Kurdistan, Iraq. Electronic address:
Introduction: Hydatid cysts are among many cysts that can develop in the pancreas. Both the size and location of these cysts significantly influence clinical presentation and surgical approach required for management. This study aims to review the literature concerning pancreatic hydatic cysts, their presentations, and management strategies.
View Article and Find Full Text PDFPredictive Factors for Fertility of Daughter Cysts in Hepatic Cystic Echinococcosis and Insights into the Origin of Daughter Cysts.
Surg Infect (Larchmt)
November 2024
Faculty of Medicine, Department of General and Digestive Surgery, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Article Synopsis
- The study investigates the fertility of daughter cysts (DC) from hepatic echinococcal cysts to understand their origin, amidst ongoing debates about their developmental potential.
- A total of 248 DC from 27 cysts in 21 patients were analyzed, revealing a fertility rate of 64.5%, with specific factors such as cyst size, DC size, and WHO classification type CE2 significantly influencing fertility.
- The results indicate most DC were fertile, and the absence of hooks in infertile DC challenges existing theories about their formation.
Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond.
Parasitology
November 2024
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Article Synopsis
- Human alveolar echinococcosis is a challenging parasitic disease that is hard to treat and often untreated, leading to high healthcare costs.
- Current treatment relies on albendazole, which isn't fully effective and can have serious side effects, highlighting the need for better options.
- Pyronaridine, an antimalarial drug, has shown promising results in mouse models for treating the disease, significantly reducing parasite size and counts compared to albendazole, and could serve as an alternative therapy, while another compound, pirenzepine, also shows potential for further research.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!