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Odontogenic cutaneous fistulas are abnormal connections between the oral cavity and skin, often mistaken for skin infections. They typically result from dental infections but may also arise from salivary gland issues, tumors, or congenital anomalies. Accurate diagnosis is essential to prevent complications like infection, osteomyelitis, and discomfort.
View Article and Find Full Text PDFMinimal change disease in treatment-naïve hepatitis C virus infection: A case report and literature review.
Clin Nephrol Case Stud
January 2025
Department of Medicine.
Minimal change disease (MCD) accounts for 10 - 15% of idiopathic nephrotic syndromes in adults. Chronic hepatitis C virus (HCV) infection is rarely ascribed as a cause of MCD and was previously associated with interferon-based therapy. MCD in treatment-naïve chronic HCV infection is extremely rare, with only 3 cases reported in the literature.
View Article and Find Full Text PDFStrategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration.
Int J Nanomedicine
January 2025
Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. Nanocrystal formulations offer a promising approach for improving the dissolution rate and saturation solubility. These formulations are applicable for various routes of administration, with each presenting unique opportunities and challenges posed by the physiological barriers.
View Article and Find Full Text PDFPhysicochemical Properties of Curen® Filaments Versus Nylon Filaments in Toothbrush Bristles: An In Vitro Study.
Cureus
December 2024
Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, IND.
Background Toothbrush manufacturers commonly use bristle materials such as nylon, polybutylene terephthalate, polypropylene, polyethylene terephthalate, boar hair, bamboo, carbon fiber, silicone, polylactic acid, or their modifications such as Curen. Nylon filaments have long been demonstrated to be durable and are widely used, but not much is known regarding the performance of Curen filaments compared to nylon filaments. This in vitro study compared the stiffness, abrasion potential, abrasion resistance, and bristle surface changes of Curen and nylon filaments.
View Article and Find Full Text PDFCritical updates on oral insulin drug delivery systems for type 2 diabetes mellitus.
J Nanobiotechnology
January 2025
School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related complications. However, given the injectable nature of exogenous insulin, apprehensions regarding its safety and the difficulties associated with its administration have hindered its widespread and prompt utilization.
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