Frequency distribution of several genetic markers was studied in ethnic Russians from the Moscow, Bryansk, Ryazan', Kostroma, Novgorod, Arkhangel'sk, and Sverdlovsk oblasts and Udmurtiya. Systems AB0, RH, HP, TF, GC, PI, C'3, ACP1, PGM1, ESD, GLO1, 6PGD, and AK were analyzed in most samples. New data on informative polymorphic genetic loci showed that the Russian gene pool mostly displays Caucasoid features. In addition, Y-chromosomal short tandem repeats (STRs) DYS19, DYS390, and YCAII were analyzed in the Russian samples. STRs of the chromosome are particularly valuable for elucidating ethnogenetic processes in Eastern Europe. Frequency distributions of the Y-chromosomal markers in Russians were intermediate between those of West European populations and eastern Finno-Ugric ethnoses of the Volga region. A marked longitudinal gradient was revealed for frequencies of several molecular markers.
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J Appl Microbiol
January 2025
G.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS; 690022 Vladivostok, Russia.
Aims: The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of marine fungal cerebroside flavuside B (FlaB) on Staphylococcus aureus-infected keratinocytes in in vitro skin wounds and to identify FlaB targets in bacterial and human cells.
Methods And Results: A combination of ELISA, plate spectrofluorimetry, and flow cytometry with fluorescence dye staining, scratch assay, and real-time cell imaging techniques was used to investigate the effects of FlaB on S. aureus-infected HaCaT keratinocytes.
Nat Commun
January 2025
Goethe University Frankfurt, Institute for Cardiovascular Physiology, Frankfurt, Germany.
The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a central role in cell type- and context-dependent gene expression. Despite the absence of a defined DNA recognition motif, SWI/SNF binds lineage specific enhancers genome-wide where it actively maintains open chromatin state.
View Article and Find Full Text PDFBiosystems
December 2024
Institute of Philosophy and Law, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; Department of International Relations and Regional Studies, Novosibirsk State Technical University, Novosibirsk, Russia.
This article presents a refinement of theoretical explanations of the main stages of linguistic and cognitive evolution in anthropogenesis. The concepts of language, consciousness, self-consciousness, the self, the unconscious, the subconscious, and the relation between free will and determinism remain at the center of active and complex debates in philosophy and neuroscience. A basic theoretical apparatus comprising the central concepts of "concern" and "providing structure" (an extension of the biological concept of "adaptation") develops the paradigm of the extended evolutionary synthesis.
View Article and Find Full Text PDFAdv Gerontol
January 2025
Belgorod State National Research University, 85 build. 10 Pobedy str., Belgorod 308015, Russian Federation, e-mail:
Adv Gerontol
January 2025
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo av., St. Petersburg 197110, Russian Federation, e-mail:
Cellular aging is the inability of structures to proliferate (further division) and repair damage while maintaining metabolic activity. The key well-known factors of cellular aging are the processes of DNA damage, telomere shortening, the development of oxidative stress and epigenetic changes. The above factors provoke the development of a pro-inflammatory environment, leading to errors in gene expression and metabolic dysregulation, thereby affecting the development of age-related diseases that contribute to pathological changes in the functions of tissues and organs.
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