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INCUOLATION THE BOTULINUM TOXIN-B IN THE ZYGOMITICUS OF THE RAT, FOLLOWED BY EVALUATION IT'S EFFECT HISTOLOGICALLY ON THE ZYGOMATIC BONE.
Georgian Med News
November 2024
1Department of biology, College of Education for Women, University of Kirkuk, Iraq.
Background: Botulinum toxin is an attenuated neurotoxin of Clostridium Botulinum gram positive bacterial, which is used in medication sialorrhea, cervical dystonia, hyperhidrosis and non-surgical cosmetic operation (aesthetic) such as facial wrinkles and reduced the bulky appearance hypertrophied of masseter muscle. This study was designed to revealed the effect of zygomiticus inoculation of botulinum toxin B in zygomatic muscle of rats on zygomatic bone.
Methods: A total of 25 male albino rats (200-260 gm) were injected facial intramuscular by a single dose of 2.
TGF-β3 Restrains Osteoclastic Resorption Through Autophagy.
Bioengineering (Basel)
November 2024
State Key Laboratory of Bioactive Molecules and Drug Gability Assessment, Jinan University, No. 855 East Xingye Avenue, Guangzhou 510632, China.
While TGF-β3 promoted defect healing in a primate baboon skull defect model and patients, it remains unclear whether TGF-β3 affects the formation of osteoclasts and bone resorption between osteogenesis and osteolysis. Analysis of the full transcriptome of hPDLSCs (human periodontal ligament stem cells) revealed that the expression of RANKL was significantly up-regulated after TGF-β3 treatment during osteogenesis, which suggests its involvement in clock-controlled autophagy in bone metabolism. TRAP staining and bone resorption lacunae were used to assess the osteoclasts formed from RANKL-induced differentiated BMMs.
View Article and Find Full Text PDFApplication of artificial intelligence-based detection of furcation involvement in mandibular first molar using cone beam tomography images- a preliminary study.
BMC Oral Health
December 2024
Department of Medical Diagnostic Imaging, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Background: Radiographs play a key role in diagnosis of periodontal diseases. Deep learning models have been explored for image analysis in periodontal diseases. However, there is lacuna of research in the deep learning model-based detection of furcation involvements [FI].
View Article and Find Full Text PDFExploring Anatomical Variations in the Bony Architecture of the Greater Palatine Canal in Dry Bones.
Cureus
October 2024
Department of Medical Sciences, Western University, London, CAN.
Article Synopsis
- The greater palatine canal (GPC) is crucial for accessing the maxillary division of the trigeminal nerve, but anatomical variations can complicate surgeries in this area, necessitating a clear understanding of both normal and anomalous anatomy.
- This study aims to investigate the GPC's bony structure in 30 dried skull specimens to identify anatomical variations and improve existing knowledge, which is often inconsistent and lacks detail.
- By systematically documenting these variations, the research seeks to enhance clinical understanding, minimize surgical complications, and emphasize the importance of further studies in this area.
Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.
Head Neck
February 2025
Guided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Purpose: Radiotherapy (RT) plays a crucial role in head and neck (HN) cancer treatment. Nevertheless, it can lead to serious and challenging adverse events such as osteoradionecrosis (ORN). A preclinical rabbit model of irradiated bone and ORN is herein proposed, with the aim to develop a viable model to be exploited for investigating new therapeutic approaches.
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