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Gender differences in recurrent coronary events; the FINMONICA MI register. | LitMetric

AI Article Synopsis

  • Male gender is a significant risk factor for first myocardial infarction (MI), but women may have a worse long-term prognosis after surviving their first MI compared to men.
  • The study involved 4,900 MI survivors aged 25-64, revealing that women were generally older and had higher rates of hypertension and diabetes at the time of their first MI.
  • Despite men showing a greater risk of fatal coronary heart disease and overall mortality than women, the number and timing of recurrent MI events were similar between genders.

Article Abstract

Background: Male gender is an established risk factor for first myocardial infarction, but some studies have suggested that among myocardial infarction survivors, women fare worse than men. Therefore, we examined the long-term prognosis of incident myocardial infarction survivors in a large, population-based MI register, addressing gender differences in mortality as well as the number of events and time intervals between recurrent events.

Methods And Results: Study subjects included 4900 men and women, aged 25-64 years, with definite or probable first myocardial infarctions who were alive 28 days after the onset of symptoms. At first myocardial infarction, women were older and more likely to be hypertensive or diabetic than men, and had a greater proportion of probable vs definite events. After adjustment for age and geographic region, men had 1.74 times the risk of fatal coronary heart disease relative to women (hazard ratio=1.63 and 1.55 for cardiovascular disease and all-cause mortality, respectively) over an average of 5.9 years of follow-up. Number and time intervals between any recurrent event--fatal and non-fatal--did not differ by gender.

Conclusion: These data suggest that men are far more likely to have a fatal recurrent event than women despite comparable numbers of events.

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Source
http://dx.doi.org/10.1053/euhj.2000.2501DOI Listing

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