[structure in text] Quaternary ammonium fluorides were found to be efficiently generated in situ from the corresponding ammonium hydrogensulfates by treatment with commercially available potassium fluoride dihydrate (KF.2H(2)O) in THF and directly used as a fluoride source for the generation of carbon nucleophiles from organosilicon compounds. This method can be successfully applied to the preparation of structurally well-defined, C(2)-symmetric chiral quaternary ammonium fluorides of type 1 (X = F), thereby allowing catalytic enantioselective Mukaiyama-type aldol reactions under mild conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol000382d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antimicrobial Polymer via ROMP of a Bioderived Tricyclic Oxanorbornene Lactam Derivative.
ACS Appl Bio Mater
January 2025
Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
The rapid emergence of multidrug-resistant (MDR) bacteria represents a critical global health threat, underscoring the urgent need for alternative antimicrobial strategies beyond conventional antibiotics. In this study, we report the synthesis of novel biobased antimicrobial polymers bearing quaternary ammonium salts, derived from sustainable feedstocks, maleic anhydride, dimethylaminobenzaldehyde, and furfurylamine. The functional tricyclic oxanorbornene lactam monomer is polymerized via ring opening metathesis polymerization, yielding well-defined polymers with controlled molar masses and low dispersity.
View Article and Find Full Text PDFEffectiveness of potassium peroxymonosulfate against enveloped viruses using an aqueous phase and its application on various contaminated carrier surfaces and artificially avian influenza virus-contaminated clothes.
Vet World
November 2024
Department of Animal Biotechnology, Mahanakorn University of Technology, Bangkok, Thailand.
Background And Aim: Potassium peroxymonosulfate (PPMS) is a broad-spectrum disinfectant that oxidizes viral protein capsids. The effectiveness of PPMS in killing viruses depends on several factors, including its concentration, contact time, and present of organic materials. This study evaluated the efficacy of PPMS in an aqueous phase.
View Article and Find Full Text PDFSulfonium Moieties as Ammonium Bioisosteres: Novel Ligands for the Alpha7 Nicotinic Acetylcholine Receptor.
J Med Chem
January 2025
Department of Pharmaceutical Sciences, Medicinal Chemistry Section "Pietro Pratesi", University of Milan, Via L. Mangiagalli 25, Milan 20133, Italy.
In the pressing quest of novel treatments for chronic pain, α7 nAChR silent agonists show efficacy as anti-inflammatory modulators and represent a promising strategy. Recent findings reveal that a sulfonium ion can replace the quaternary ammonium nitrogen as an alternative pharmacophore for nAChR silent activation. This study reports the design, synthesis, and electrophysiological evaluation of a new series of sulfonium-based derivatives inspired by the archetypal silent agonist NS6740.
View Article and Find Full Text PDFChitosan-based hydrogels: A comprehensive review of transdermal drug delivery.
Int J Biol Macromol
January 2025
Institute of Microengineering and Nanoelectronics (IMEN), The National University of Malaysia, Bangi, Selangor 43600, Malaysia.
This article provides a comprehensive review of chitosan-based hydrogels for transdermal drug delivery. It covers various aspects including the chemical structure of chitosan and its derivatives, crosslinking agents, hydrogel morphology, and drug loading and release behaviors. The review draws on 16 studies sourced from Scopus, focusing on how the composition and structure of hydrogels influence drug release.
View Article and Find Full Text PDFUnignorable environmental risks: Insight into differential responses between biofilm and plastisphere in sulfur autotrophic denitrification system upon exposure to quaternary ammonium compounds.
J Hazard Mater
January 2025
National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Department of Environmental Engineering, Beijing University of Technology, Beijing 100124, China.
Concerns of quaternary ammonium compounds (QACs) and microplastics (MPs) as emerging containments accumulating in wastewater treatment plants (WWTPs) have attracted much attention. Plastisphere with distinctive microbial communities might also be the repository for pathogens and resistance genes (RGs). Thus, the effects of three representative QACs with different concentrations on biofilm and plastisphere were studied in sulfur autotrophic denitrification (SAD) system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!