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A Case of Hepatocellular Carcinoma Complicated by Fulminant Type 1 Diabetes Mellitus Shortly After Initiation of Durvalumab Plus Tremelimumab.
Intern Med
December 2024
Department of Gastroenterology and Hepatology, Saitama Medical University, Japan.
A 64-year-old man with cirrhosis was diagnosed with unresectable hepatocellular carcinoma and treated with a combination of durvalumab and tremelimumab. The patient had no history of diabetes mellitus. Three weeks later, the patient developed general fatigue, dry mouth, and polyuria.
View Article and Find Full Text PDFA Novel Preoperative Classification System for Selecting Suitable Surgeries in Liver Transplant Patients with Portal Vein Cavernous Transformation.
J Invest Surg
December 2024
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Background: To evaluate the new preoperative Changgung classification (CC) system of portal vein thrombosis (PVT) in choosing suitable operative procedures to reconstruct portal veins during liver transplantation (LT) in patients with portal vein cavernous transformation (PVCT).
Methods: This retrospective observational study analyzed data from allograft LTs performed for various liver diseases.
Results: The study included 22 males and 4 females with LT indications comprising cirrhosis ( = 9), hepatocellular carcinoma ( = 12), PVCT ( = 2), liver failure from fulminant hepatitis B ( = 1), dysfunction of transplanted liver ( = 1), and chronic rejection of transplanted liver ( = 1).
Exploration of the clinical characteristics and potential mechanisms of liver injury induced by proton pump inhibitors.
Expert Opin Drug Saf
October 2024
Department of Pharmacy, Municipal Hospitals Affiliated to Taizhou University, Taizhou, Zhejiang, China.
Background And Aims: Data related to clinical characteristics and potential mechanisms of proton pump inhibitors (PPIs)-related liver injury are sparse, thus the purpose of this study is to summarize the clinical features and molecular mechanisms of PPIs-induced liver injury.
Methods: We collected case report on liver injury induced by PPIs in English and Chinese for retrospective analysis. Clinical and pathological data and outcomes were obtained and analyzed.
Detection of hepatitis B virus genotypes in a group of hepatitis B virus-infected patients in central and northern Sri Lanka.
Access Microbiol
October 2024
National Hospital, Kandy 20000, Sri Lanka.
Hepatitis B infection causes a spectrum of clinical diseases varying from asymptomatic infection to severe or fulminant acute hepatitis, chronic liver disease, cirrhosis and hepatocellular carcinoma. Hepatitis B virus (HBV) genotypes appear to influence transmission dynamics, clinical outcomes and responses to antiviral therapy. However, hepatitis B genotyping has been poorly investigated in Sri Lanka.
View Article and Find Full Text PDFInterventions in Budd-Chiari syndrome: an updated review.
Abdom Radiol (NY)
September 2024
Department of Surgical Gastroenterolgy, All India Institute of Medical Sciences, Bhubaneswar, 751019, India.
Article Synopsis
- * Different regions have varying causes of BCS; in the West, hepatic vein thrombosis is common, while in Asia, membranous and short occlusions are more prevalent, impacting treatment strategies.
- * Interventional treatments like angioplasty and shunting can alleviate the condition more effectively than surgery, although complications may arise, and some patients may ultimately need a liver transplant if therapies fail.
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