Conditioned place preference (CPP) is a learning paradigm requiring formation of associations between reward and particular locations. White and McDonald (Behav Brain Res 1993;55:269-281) demonstrated that amygdala (AMG) lesions impair, while fornix (Fx) lesions enhance learning of this task. In the present experiments, we replicated the effects of AMG and Fx lesions, but we also found that complete hippocampal (HPC) lesions interfere with normal performance. Thus, the effects of Fx and HPC lesions on CPP are opposite. This is in contrast with spatial learning in the water maze. Because it has been demonstrated that damage of dorsal HPC interferes to a greater extent with spatial learning than damage of ventral HPC, we also tested animals with either dorsal or ventral HPC disruptions on CPP. Lesions limited to dorsal HPC were followed by impairment on this task. In contrast, lesions limited to ventral HPC resulted in enhanced learning. We argue that Fx and HPC lesions do not have interchangeable effects in all learning paradigms. To explain the complex pattern of results presently obtained, we propose a novel hypothesis regarding behavioral functions of HPC neural circuits. Implications regarding the interaction between memory systems are also considered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hipo.1036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hippocampal Lesions in Male Rats Produce Retrograde Memory Loss for Over-Trained Spatial Memory but Do Not Impact Appetitive-Contextual Memory: Implications for Theories of Memory Organization in the Mammalian Brain.
J Neurosci Res
January 2025
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Article Synopsis
- The study investigates the role of the hippocampus (HPC) and amygdala in memory formation, particularly focusing on retrograde amnesia that occurs after HPC disruption.
- Findings reveal that damage to the HPC does not affect conditioned place preference (CPP) tasks, which rely on the basolateral amygdala, suggesting that not all learning tasks require HPC involvement.
- Additional experiments using the Morris water task indicate that while HPC damage impairs performance, other memory networks can't fully compensate when certain training methods are used, highlighting the complexity of memory processing.
Splice site and de novo variants can cause PLCG2-associated immune dysregulation with cold urticaria.
J Allergy Clin Immunol
December 2024
Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, Md. Electronic address:
Article Synopsis
- PLCγ2 is a key signaling molecule involved in immune regulation, and its variants can lead to conditions like PLCγ2-associated immune dysregulation (PLAID), particularly PLAID with cold urticaria (PLAID-CU), caused by specific genetic mutations.
- Researchers conducted a study combining RNA sequencing and whole genome sequencing to identify genetic lesions in patients with antibody deficiency and known PLAID-CU cases.
- The study found that two probands had novel PLCG2 transcripts with in-frame deletions linked to splice site mutations and deletions, which resulted in impaired ERK phosphorylation in a model system, highlighting the role of these genetic alterations in PLAID-CU.
Hemangiopericytoma following allogeneic hematopoietic stem cell transplantation in a patient with primary plasma cell leukemia: the first case report and literature review.
Front Oncol
November 2024
Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, China.
Background: Hemangiopericytoma (HPC) is a rare secondary tumor after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which has not been reported in the literature. Herein, we reported a case of HPC after allo-HSCT.
Case Description: We reported a case of a middle-aged female patient with primary plasma cell leukemia who presented lumbosacral pain and right lower limb pain and numbness on1684 days post-transplant.
Early Cervical Cancer Diagnosis with SWIN-Transformer and Convolutional Neural Networks.
Diagnostics (Basel)
October 2024
Enkoy LLC, Lanham, MD 20706, USA.
Early diagnosis of cervical cancer at the precancerous stage is critical for effective treatment and improved patient outcomes. This study aims to explore the use of SWIN Transformer and Convolutional Neural Network (CNN) hybrid models combined with transfer learning to classify precancerous colposcopy images. Out of 913 images from 200 cases obtained from the Colposcopy Image Bank of the International Agency for Research on Cancer, 898 met quality standards and were classified as normal, precancerous, or cancerous based on colposcopy and histopathological findings.
View Article and Find Full Text PDFDissociations in perceptual discrimination following selective damage to the dentate gyrus versus CA1 subfield of the hippocampus.
Cortex
October 2024
Department of Psychology, York University, Toronto, ON, Canada; Rotman Research Institute at Baycrest Hospital, Toronto, ON, Canada; Centre for Integrative and Applied Neuroscience, York University, Toronto, ON, Canada. Electronic address:
The hippocampus (HPC) is well-known for its involvement in declarative (consciously accessible) memory, but there is evidence that it may also play a role in complex perceptual discrimination. Separate research has demonstrated separable contributions of HPC subregions to component memory processes, with the dentate gyrus (DG) required for mnemonic discrimination of similar inputs and the CA1 subfield required for retention and retrieval, but contributions of these subregions to perceptual processes is understudied. The current study examined the nature and extent of a double dissociation between the dentate gyrus (DG) to discrimination processes and CA1 subfield to retention/retrieval by testing two unique individuals with bilateral damage to the DG (case BL) and CA1 (case BR).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!