Unlabelled: The aim of the study was to estimate clinical symptoms and gastric emptying in functional dyspepsia (f.d.) before and after treatment.
Methods: 40 patients were examined. Control group consisted of 10 healthy volunteers. The severity of symptoms was estimated in 0-3 score. Gastric emptying was measured with radionuclide method. Examinations were performed prior and after treatment with famotidine (group I), cisaprid + famotidine (group II), cisaprid (group III), eradication of H.p. (group IV).
Results: Significantly delayed gastric emptying was observed in patients with f.d. Severity of symptoms score was significantly reduced after treatment, and was: group. I 13.8-11.2, group II. 14.8-8.8, group III 13.7-6.9, group IV 13.3-9.0. Gastric emptying was improved after treatment in groups: II 64.3-45.5 and III 65.1-46.7 respectively. In groups I and IV there was a minor nonsignificant change in gastric emptying.
Conclusions: 1. Gastric emptying is significantly delayed in patients with f.d. 2. Prokinetic therapy with cisapride results in the improvement of gastric emptying together with alleviation of clinical symptoms of f.d. 3. Antisecretory treatment with famotidine and eradication of Helicobacter pylori do not effect gastric emptying, but exerts positive clinical response.
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