The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (Visipaque, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in renal clearance. Seven centers enrolled 43 patients. Cardiac catheterization was performed in 41 patients and cranial computed tomography in 2. Patients were entered into 5 age groups: newborn to <2 months, 2 to <6 months, 6 months to <1 year, 1 to <3 years, and 3 to
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s002460010208 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The interaction between iodinated X-ray contrast agents and macrocyclic GBCAs provides a signal enhancement in T -weighted MR images: Insights into the renal excretion pathways of Gd-HPDO3A and iodixanol in healthy mice.
Magn Reson Med
July 2022
Istituto di ricovero e cura a carattere scientifico, Naples, Italy.
Purpose: This work aims to investigate the supramolecular binding interactions that occur between iodinated X-ray contrast agents (CAs) and macrocyclic gadolinium (Gd)-based MRI contrast agents (GBCAs). This study provides some new insights in the renal excretion pathways of the two types of imaging probes.
Methods: The water-proton relaxivities (r ) of clinically approved macrocyclic and linear GBCAs have been measured in the presence of different iodinated X-ray contrast agents at different magnetic field strengths in buffer and in serum.
Relationship between Dilution Magnification of Non-Ionic Iodinated Contrast Medium and Amplification Effect of Radiation Dose.
J Neuroendovasc Ther
October 2022
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Objective: Neuroendovascular treatments are less invasive than surgical clipping. However, the number of fluoroscopy runs may be greater when a contrast medium is used than when routine angiography is performed. Several recent studies have suggested that an iodinated contrast medium causes an increase in the radiation dose.
View Article and Find Full Text PDFCerebrospinal Fluid Characterization in Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs.
Int J Toxicol
February 2021
Charles River Laboratories Laval, Quebec, Canada.
Intrathecal administration is an important route for drug delivery, and in pharmacology and toxicology studies, cerebrospinal fluid (CSF) collection and analysis is required for evaluating blood-brain barrier penetration and central nervous system exposure. The characteristics of CSF in commonly used nonrodent models are lacking. The purpose of this study is to evaluate and provide some insights into normal cellular and biochemical composition of CSF as well as diffusion potential following intrathecal injection across several nonrodent species.
View Article and Find Full Text PDFImpact of CT Injector Technology and Contrast Media Viscosity on Vascular Enhancement: Evaluation in a Circulation Phantom.
Br J Radiol
May 2020
Bayer AG, Radiology R&D, 13353 Berlin, Germany.
Objective: To assess the impact of piston-based peristaltic injection system technology and contrast media viscosity on achievable iodine delivery rates (IDRs) and vascular enhancement in a pre-clinical study.
Methods: Four injectors were tested: MEDRAD Centargo, MEDRAD Stellant, CT Exprès, and CT motion using five contrast media [iopromide (300 and 370 mgI ml), iodixanol 320 mgI ml, iohexol 350 mgI ml, iomeprol 400 mgI ml]. Three experiments were performed evaluating achievable IDR and corresponding enhancement in a circulation phantom.
Aging does not change the compressive stiffness of mandibular condylar cartilage in horses.
Osteoarthritis Cartilage
December 2018
Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands. Electronic address:
Objective: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical properties of the temporomandibular joint (TMJ) cartilage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!