The extraction conditions of Fructus Psoraleae were studied with orthogonal test, taking the contents of psoralen and isopsoralen as indexes and smesh degree, alcohol concentration, alcohol volume, immersion time and immersion times as factors. The results showed the optimal extraction process is pulverizing the herbs into 20 meshes powder, 6 times volume of 55% alcohol immersed three times and two days every time.
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Phytochemistry
February 2025
Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:
Immunopharmacol Immunotoxicol
December 2024
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Reports of traditional Chinese medicine (TCM)-related liver injury have increased over recent years; however, identifying susceptibility-related components and biomarkers remains challenging due to the heterogeneous nature of TCM and idiosyncratic drug-induced liver injury (IDILI). (PF) and (EF), commonly found in TCM prescriptions, have been implicated in IDILI, but their constituents and underlying mechanisms are poorly understood. In this study, we identified bavachin (Bav) and icariin (Ica) as susceptibility components for IDILI in PF and EF using a TNF-α-mediated mouse model.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine Guangzhou 510405,China.
Salt-processed Psoraleae Fructus is a commonly used tonic in clinical practice. However, its usage is restricted due to the inherent toxicity. The covalent modification of proteins by reactive metabolites(RMs) plays a role in the hepatotoxicity of salt-processed Psoraleae Fructus.
View Article and Find Full Text PDFToxicology
December 2024
Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin 301617, China. Electronic address:
Psoralen is a main active molecule of the traditional Chinese herb medicine Fructus Psoraleae. Our previous studies have shown that psoralen induced liver injury through the endoplasmic reticulum stress (ERS) signaling pathways. In this article, we studied whether the ERS inhibitor, 4-phenylbutyrate acid (4-PBA) could inhibit the liver toxicity caused by psoralen, and explored the underlying mechanisms.
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