Nicorandil is an anti-anginal agent that has been used in the United Kingdom for over 6 years and is becoming increasingly popular. It induces coronary and peripheral vasodilatation via a dualistic mode of action, mediated by the opening of potassium-ATP channels (K(ATP)) and its nitrate effect by stimulation of adenyl cyclase, with an increase in cGMP levels. Comparison to nitrates and other anti-anginal agents have shown it to be of equal efficacy in relieving ischaemic symptoms. Recent evidence suggests a role for nicorandil as a myocardial preconditioning agent but this may be limited by systemic vasodilatation. There is ongoing research into its role in improving the long-term outcome of patients with ischaemic heart disease (IHD). It has been shown to be of proven efficacy in the treatment of IHD and further research will clarify other uses of this agent.
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| http://dx.doi.org/10.1517/14656566.2.5.845 | DOI Listing |
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Nicorandil restores endothelial cell Kir6.2 expression to alleviate neuropathic pain in mice after chronic constriction injury.
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Orthopedic Microsurgical Reconstruction Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China. Electronic address:
The clinical management of neuropathic pain (NP) remains a significant challenge, as current pharmacological treatments do not fully meet clinical needs. Nicorandil, a potassium ATP channel agonist widely used in cardiovascular medicine, has recently been shown to have significant potential for analgesia. This study aimed to investigate the effects and mechanisms of nicorandil in a chronic constriction injury (CCI) mouse model.
View Article and Find Full Text PDFUnraveling the Plausible Role of Potassium Channel Openers in Alzheimer's Disease.
Cent Nerv Syst Agents Med Chem
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Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, 201301, India.
Reno-protective effect of nicorandil and pentoxifylline against potassium dichromate-induced acute renal injury via modulation p38MAPK/Nrf2/HO-1 and Notch1/TLR4/NF-κB signaling pathways.
J Trace Elem Med Biol
September 2024
Department of Medical Physiology, Faculty of Medicine, Menoufia University, Shebeen ElKom 32511, Egypt.
Background: Occupational and environmental exposure to chromium compounds such as potassium dichromate (PDC) (KCrO) has emerged as a potential aetiologic cause for renal disease through apoptotic, and inflammatory reactions. The known potent antioxidants such as nicorandil (NIC) and/or pentoxifylline (PTX) were studied for their possible nephroprotective effect in PDC-treated rats.
Methods: Forty male Wistar rats were divided into five groups; control, PDC group, NIC+PDC, PTX+PDC group, and combination+PDC group.
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Br J Pharmacol
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Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Article Synopsis
- * In a rat model, nicorandil showed promising results by reducing damage indicators and exhibiting antioxidant and anti-inflammatory effects on lung tissue.
- * The study revealed that nicorandil alters specific molecular pathways related to inflammation and cell stress, making it a compelling candidate for more extensive clinical trials to confirm its efficacy in lung injury prevention.
Mechanism of action and neuroprotective role of nicorandil in ischemic stroke.
Heliyon
February 2024
Histomorphometry & Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nicorandil is a dual mechanism anti-anginal agent that acts as a nitric oxide (NO) donor and a potassium (K) channel opener. Recent studies have evaluated the effect of nicorandil on ischemic stroke. Neurons have a low tolerance to hypoxia and therefore the brain tissue is significantly vulnerable to ischemia.
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