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A surgical orthotopic xenograft approach with immune response for colorectal cancer research.
Animal Model Exp Med
January 2025
Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
The high morbidity and mortality of colorectal cancer (CRC) is a major challenge in clinical practice. Although a series of alternative research models of CRC have been developed, appropriate orthotopic animal models that reproduce the specific clinical response as well as pathophysiological immune features of CRC are still lacking. In the current study, we constructed a CRC orthotopic xenograft model by implanting the tumor tubes at the colorectum of mice and monitored the model development using bioluminescence imaging.
View Article and Find Full Text PDFConsensus-Based Guidelines for Best Practices in the Selection and Use of Examination Gloves in Healthcare Settings.
Nurs Rep
January 2025
Escola Enfermagem (Porto), Faculdade Ciências da Saúde e Enfermagem, Universidade Católica Portuguesa, 4169-005 Porto, Portugal.
Background/objectives: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) present significant challenges in modern healthcare, leading to increased morbidity, mortality, and healthcare costs. Examination gloves play a critical role in infection prevention by serving as a barrier to reduce the risk of cross-contamination between healthcare workers and patients. This manuscript aims to provide consensus-based guidelines for the optimal selection, use, and disposal of examination gloves in healthcare settings, addressing both infection prevention and environmental sustainability.
View Article and Find Full Text PDFPedicled Radial Forearm "Free" Flap for Intraoral Reconstruction Based on an Unexpectedly High Origin of the Radial Artery-Case Report.
Clin Pract
December 2024
Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia.
Radial forearm free flap (RFFF) is considered one of the workhorses in modern head and neck reconstruction surgery due to its technical simplicity, versatility and less time-consuming harvest. In this report, we present the case of a 56-year-old woman with sublingual squamous cell carcinoma (SCC) who underwent surgical resection and reconstruction of the defect with a RFFF. The preoperative Allen test showed normal blood flow, and the ultrasound did not recognize any blood vessel abnormalities in the left arm.
View Article and Find Full Text PDFIntegrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering.
Bioengineering (Basel)
January 2025
Department of Physiology, School of Medicine, University of Patras, Asklepiou Street 1, Rio, 26504 Patras, Greece.
The anterior cruciate ligament (ACL) is one of the most injured ligaments, with approximately 100,000 ACL reconstructions taking place annually in the United States. In order to successfully manage ACL rupture, it is of the utmost importance to understand the anatomy, unique physiology, and biomechanics of the ACL, as well as the injury mechanisms and healing capacity. Currently, the "gold standard" for the treatment of ACL ruptures is surgical reconstruction, particularly for young patients or athletes expecting to return to pivoting sports.
View Article and Find Full Text PDFSalivary Glands: Function, Dysfunction, Regeneration, and Repair.
Discov Med
January 2025
Department of Stomatology, Faculty of Dentistry, University of Murcia, 30008 Murcia, Spain.
Salivary gland dysfunctions are common conditions variously related to aging, inflammatory players, and any other factor able to alter their normal physiology. These conditions may significantly impact oral and systemic health, affecting the overall quality of life. Over time, numerous therapeutic strategies have been explored to regenerate, repair, or replace injured salivary glands, focusing on those molecular and cellular mechanisms able to be safely translated into a clinical landscape.
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