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http://dx.doi.org/10.1021/ja00839a077 | DOI Listing |
Int J Dermatol
April 2017
Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.
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