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λ-cyhalothrin induced sex-specific inflammation, glia activation and GABAergic interneuron disruption in the hippocampus of rats.
BMC Pharmacol Toxicol
January 2025
Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Background: Glia mediated neuroinflammation and degeneration of inhibitory GABAergic interneurons are some of the hall marks of pyrethroid neurotoxicity. Here we investigated the sex specific responses of inflammatory cytokines, microglia, astrocyte and parvalbumin positive inhibitory GABAergic interneurons to λ-cyhalothrin (LCT) exposures in rats.
Methods: Equal numbers of male and female rats were given oral corn oil, 2 mg/kg.
C-terminal amides mark proteins for degradation via SCF-FBXO31.
Nature
January 2025
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites. Such modifications have been proposed to trigger the selective removal of chemically marked proteins; however, identifying modifications that are sufficient to induce protein degradation has remained challenging.
View Article and Find Full Text PDFLG1 promotes preligule band formation through directly activating ZmPIN1 genes in maize.
J Genet Genomics
January 2025
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Laboratory for Lingnan Modern Agriculture, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China. Electronic address:
Increasing plant density is an effective strategy for enhancing crop yield per unit land area. A key architectural trait for crops adapting to high planting density is smaller leaf angle (LA). Previous studies have demonstrated that LG1, a SQUAMOSA BINDING PROTEIN (SBP) transcription factor, plays a critical role in LA establishment.
View Article and Find Full Text PDFEffect of endogenous protein on starch before and after post-harvest ripening of corn: Structure, pasting, rheological and digestive properties.
Food Chem
January 2025
College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China; National Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, 130118, China. Electronic address:
This work revealed the effects of endogenous proteins on the structural, physicochemical, and digestive properties of starch in corn before and after ripening and explored the binding mechanism of proteins with starch. The microstructure showed that the postharvest ripening process resulted in a thinning of the protein layer on the surface of starch particle. After the removal of protein, the uniformity of the sample surface increased, with tiny pores.
View Article and Find Full Text PDFEffects of multienzyme supplementation on energy and nutrient digestibility in various feed ingredients for pregnant gilts.
J Anim Sci
January 2025
Department of Animal Science, South Dakota State University, Brookings, SD, 57007, USA.
The utilization of exogenous fiber-degrading enzymes in commercial swine diets is a strategy to increase the nutrient and energy density of poorly digestible ingredients. In a prior set of studies, dietary multienzyme blend (MEblend) supplementation increased the apparent total tract digestibility (ATTD) of nutrients, non-starch polysaccharides, and energy in complete high-fibrous gestation diets by 6% when fed to gestating sows. The current study aimed to determine the effects of MEblend (containing xylanase, β-glucanase, cellulase, amylase, protease, pectinase, and invertase activities) supplementation on ATTD of energy and nutrients of individual feedstuffs commonly used in gestating sow diets across major pork-producing regions worldwide, which differ in their fibrous components.
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