Objective: To evaluate the influence of hormonal status on somatic, psychopathological and mood symptoms in climacteric women.

Method: 122 postmenopausal women have been evaluated by the PISA-system and P.O.M.S. (Profile of Mood States) to evaluate somatic, psychopathological and mood symptoms in a 3-intervention trial (perimenopausal women, postmenopausal women on replacement therapy, and postmenopausal women without any therapy).

Result: We found no statistically significant difference among the three groups. A clear trend has however resulted: sex hormones seem to decrease the depressive mood, aggressiveness/anger and sexual dissatisfaction.

Conclusion: Our results are inconclusive but they suggest that hormones influence some psychological and mood symptoms during the climacterium.

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