Objective: The aim of this study was to analyze the fertility prognosis after conservative or radical surgery for ectopic pregnancy. Also, to identify any biological factors that may influence the fertility outcome after an ectopic pregnancy.
Methods: A retrospective study which was carried out by collating information from the patient's hospital records was performed on 137 cases of confirmed ectopic pregnancy between January 1990 and December 1995 at the Security Forces Hospital Riyadh, Kingdom of Saudi Arabia. The outcome measure of term pregnancy rate and repeat ectopic pregnancy rate was analyzed up to 3 years after the diagnosis of index ectopic pregnancy.
Results: Our results showed that the term pregnancy rates were not significantly different following radical or conservative surgical treatments for ectopic pregnancy, P > 0.05, (50% in the conservative group compared with 56% in the radical group). But equally important, the risk of a further ectopic was not increased in the radical surgery group, P >0.05 (11% in the conservative group as compared to 8% in the radical group). The incidence of intrauterine pregnancy rate (term pregnancy + miscarriage) was also comparable in each group. Multivariate regression analysis showed that the factors associated with higher fertility were age 30 years or less, past history of term pregnancy and a negative history of infertility (P < 0.05).
Conclusion: No significant difference in intrauterine pregnancy rates or repeat ectopic pregnancy rates were found after radical or conservative surgical treatment for tubal pregnancy. The patient's age, previous obstetric performance and a history of infertility significantly influenced fertility following the index ectopic pregnancy.
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J Adv Res
January 2025
Jinxin Research Institute for Reproductive Medicine and Genetics, Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu, China; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China. Electronic address:
Introduction: Despite of numerous studies of the placenta, some molecular and cellular characteristics, particularly the relationship among different cell types, have not been well understood. We aim to investigate the basic and intricate details of cellular and molecular elements in early and late phase placentas to gain better understanding of the immune regulation of human reproductive process.
Methods: A novel combination of techniques of spatial transcriptomics(ST), multiple immunohistochemistry, and a dual labeling combining immunohistochemistry and (fluorescence in situ hybridization) FISH on normal and ectopic pregnancy and animal models was employed to investigate the placenta at tissue, cell, protein and molecular levels and to trace the fetal and maternal origin of every cell in early and late placentas.
BJOG
January 2025
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Objective: To determine the diagnostic performance and clinical utility of the M4 prediction model and the NICE algorithm managing women with pregnancy of unknown location (PUL).
Design: The study has a superiority design regarding specificity for non-ectopic pregnancy for M4, given that the primary outcome of sensitivity for ectopic pregnancy (EP) is non-inferior in comparison with the NICE algorithm.
Setting: Emergency gynaecology units in Sweden.
Cureus
December 2024
Emergency, Ras Tanura General Hospital, Eastern Health Cluster, Ministry of Health, Ras Tanura, SAU.
This case highlights the critical role of early radiological screening by ultrasound in identifying uterine anomalies. In this report, we discuss a 39-year-old pregnant woman, gravida 4 para 3, and her fetus at gestational age 18 weeks. The patient was referred to the Obstetrics and Gynecology Emergency Department at Qatif Central Hospital, Saudi Arabia, from a private hospital due to an ultrasound study indicating a possible ectopic pregnancy with an abdominal fetal location.
View Article and Find Full Text PDFCureus
December 2024
Department of Obstetrics and Gynecology, School of Health Sciences, University of Patras, Patras, GRC.
Heterotopic pregnancy is defined as the simultaneous presence of an intrauterine and an extrauterine pregnancy and is considered a rare condition. As a part of this entity, heterotopic triplet pregnancy, defined as the presence of three embryos, with at least one being ectopic, is exceedingly rare. In recent years, the broad use of assisted reproductive techniques to help infertile couples has contributed to the constant rise of non-spontaneous heterotopic triplets.
View Article and Find Full Text PDFFront Cardiovasc Med
January 2025
Department of Intensive Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
A young female patient suffered cardiogenic shock after undergoing surgery for an ectopic pregnancy. Coronary artery computed tomography angiography (CTA) revealed a left main artery (LM) originating from the right coronary sinus and traveling between the aorta and pulmonary artery. We successfully resuscitated the patient with mechanical circulatory support using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and an intra-aortic balloon pump (IABP).
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